Assessment of Carotid Artery Atherosclerotic Disease by Using Three-dimensional Fast Black-Blood MR Imaging: Comparison with DSA
Assessment of Carotid Artery Atherosclerotic Disease by Using Three-dimensional Fast Black-Blood MR Imaging: Comparison with DSA
复制标题
使用三维快速黑血 MR 成像评估颈动脉粥样硬化疾病：与 DSA 比较。
DOI：
10.1148/radiol.14132687
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发表时间：
2015-02-01
期刊：
影响因子：
19.7
通讯作者：
Xu, Jianrong
中科院分区：
文献类型：
--
作者：
Zhao, Huilin;Wang, Jinnan;Xu, Jianrong
目的：评估快速三维 (3D) 黑血 (BB) 磁共振 (MR) 成像作为动脉内数字减影血管造影 (DSA) 的无创替代方案在量化中度至重度颈动脉粥样硬化疾病方面的作用。材料和方法：本研究获得了当地伦理委员会的批准和患者书面知情同意书。来自 52 名至少 50% 狭窄的患者的 65 条颈动脉接受了 3D BB MR 成像和 DSA。独立确定通过两种方式获得的定量测量结果，包括狭窄、病变长度以及是否存在斑块溃疡。使用敏感性和特异性、组内相关系数 (ICC)、Cohen k 和 Bland-Altman 分析来评估一致性。结果：3D BB MR 成像和 DSA 测量管腔狭窄的结果非常一致（ICC，0.96；95% 置信区间 [CI]：0.93，0.97）。三维 BB MR 成像还被发现具有高灵敏度 (91.7%)、特异度 (96.2%)，并且与 DSA 检测溃疡的一致性 (Cohen k, 0.85; 95% CI: 0.66, 0.99)。使用 3D BB MR 成像和 DSA 测量的病灶长度之间具有良好的一致性（ICC，0.75；95% CI：0.51，0.84）。然而，使用 3D BB MR 成像测量的病灶长度平均比使用 DSA 测量的病灶长度长 4.0 mm (P < .001)。 结论：三维 BB MR 成像是一种无创且准确的量化中度至重度颈动脉粥样硬化疾病的方法。凭借快速采集和大覆盖范围，3D BB MR 成像有潜力成为评估动脉粥样硬化严重程度的替代成像方法。 (C) 北美放射学会，2014
Purpose: To assess fast three-dimensional (3D) black-blood (BB) magnetic resonance (MR) imaging as a noninvasive alternative to intraarterial digital subtraction angiography (DSA) at quantifying moderate to severe carotid artery atherosclerotic disease.Materials and Methods: Local ethics committee approval and written informed patient consent were obtained for this study. Sixty-five carotid arteries from 52 patients with at least 50% stenosis underwent 3D BB MR imaging and DSA. Quantitative measurements, including stenosis, lesion length, and the presence or absence of plaque ulceration, obtained with the two modalities were independently determined. Sensitivity and specificity, the intraclass correlation coefficient (ICC), Cohen k, and Bland-Altman analysis were used to assess the agreement.Results: Excellent agreement in measuring luminal stenosis was found between 3D BB MR imaging and DSA (ICC, 0.96; 95% confidence interval [CI]: 0.93, 0.97). Three-dimensional BB MR imaging was also found to have high sensitivity (91.7%), specificity (96.2%), and agreement (Cohen k, 0.85; 95% CI: 0.66, 0.99) with DSA for detection of ulcers. Good agreement was found between lesion length measured by using 3D BB MR imaging and DSA (ICC, 0.75; 95% CI: 0.51, 0.84). However, lesion length measurements by using 3D BB MR imaging were, on average, 4.0 mm longer than those measured by using DSA (P < .001).Conclusion: Three-dimensional BB MR imaging is a noninvasive and accurate way to quantify moderate to severe carotid artery atherosclerotic disease. With fast acquisition and large coverage, 3D BB MR imaging has the potential to become an alternative imaging approach in evaluating the severity of atherosclerosis. (C) RSNA, 2014