Hippocampal dentate granule cell degeneration after adrenalectomy in the rat is not reversed by dexamethasone.
Hippocampal dentate granule cell degeneration after adrenalectomy in the rat is not reversed by dexamethasone.
复制标题
地塞米松不能逆转大鼠肾上腺切除术后海马齿状颗粒细胞变性。
DOI：
10.1016/0006-8993(95)00350-y
复制
发表时间：
1995
期刊：
影响因子：
2.9
通讯作者：
Neubort,S
中科院分区：
文献类型：
--
作者：
Sloviter,RS;Sollas,AL;Neubort,S
虽然有报道称肾上腺切除会导致海马齿状回颗粒细胞的选择性退化，有时甚至几乎完全退化，Azmia和他的同事最近报道(Mol.Brain Res.，19(1993)328-332)认为正常的海马体结构仍然可以通过饮用水中的地塞米松在几天内恢复。我们试图证实这一非凡的发现。大鼠肾上腺切除4个月后，给予赋形剂或地塞米松5d后处死。组织学分析显示，用赋形剂治疗的肾上腺切除大鼠表现出颗粒细胞丢失的全谱，包括轻微的甚至几乎完全的细胞丢失。地塞米松治疗的肾上腺切除大鼠与赋形剂治疗的肾上腺切除大鼠没有什么不同，事实上，表现出几乎相同的颗粒细胞丢失谱。这些结果证实了肾上腺切除可以可靠地诱导大多数动物的海马颗粒细胞变性，并表明一旦颗粒细胞丢失，地塞米松不能恢复正常的海马结构。
Although adrenalectomy has been reported to induce a selective and sometimes nearly complete degeneration of hippocampal dentate granule cells, Azmitia and colleagues recently reported (Mol. Brain Res., 19 (1993) 328–332) that normal hippocampal structure can nonetheless be restored within a matter of days by dexamethasone in the drinking water. We have attempted to confirm this remarkable finding. Four months after adrenalectomy, rats were given vehicle or dexamethasone for 5 days and then sacrificed. Histological analysis revealed that vehicle-treated adrenalectomized rats exhibited a full spectrum of granule cell loss, which spanned mild to nearly complete cell loss. Dexamethasone-treated adrenalectomized rats did not differ from vehicle-treated adrenalectomized rats and, in fact, exhibited a virtually identical spectrum of granule cell loss. These results confirm that adrenalectomy reliably induces hippocampal granule cell degeneration in a majority of animals and indicate that dexamethasone does not restore normal hippocampal structure once granule cell loss has occurred.