VARIATION IN RESPONSE OF XENOGRAFTS OF COLO-RECTAL CARCINOMA TO CHEMOTHERAPY
VARIATION IN RESPONSE OF XENOGRAFTS OF COLO-RECTAL CARCINOMA TO CHEMOTHERAPY
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DOI：
10.1038/bjc.1978.87
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发表时间：
1978-01-01
影响因子：
8.8
通讯作者：
STEEL, GG
中科院分区：
文献类型：
--
作者：
NOWAK, K;PECKHAM, MJ;STEEL, GG
在免疫抑制小鼠中建立了10种人结肠癌和直肠癌异种移植物系。第2 ~ 6代荷瘤小鼠给予最大耐受剂量的8种化疗药物治疗，并根据治疗获得的体积加倍次数估计肿瘤生长延迟。平均反应仅对应于0.5倍的延迟，但某些肿瘤系对某些药物表现出良好的反应。在大约700个接受治疗的肿瘤中，有23个未能再生。统计分析显示，不同肿瘤系之间的敏感性没有一致的差异，但美法兰、5-氟尿嘧啶和六甲基三聚氰胺是最有效的药物。一项对两种药物联合使用的研究表明，它们的给药顺序对疗效影响不大。只有4例捐献异种移植物的患者接受了化疗，但在这些患者中，有一些证据表明异种移植物的反应与患者的反应相关。
Ten xenograft lines of human colonic and rectal carcinomas were established in immune-suppressed mice. Mice bearing tumors in the 2nd-6th passage were treated with maximum tolerated doses of 8 chemotherapeutic agents and tumor growth delay was estimated in terms of the number of volume doubling times gained by treatment. The average response corresponded to a delay of only about 0.5 doubling times, but some tumor lines showed a good response to some agents. Twenty-three of about 700 treated tumors failed to regrow. Statistical analysis showed no consistent difference in sensitivity among the tumor lines, but melphalan, 5-fluorouracil and hexamethylmelamine stood out as the most effective agents. A study of 2-drug combinations showed that their order of administration had little effect on response. Only 4 patients who donated the xenografts were treated with chemotherapy, but among these there was some evidence that response in the xenografts correlated with response in the patient.