Praziquantel
Praziquantel
复制标题
DOI：
10.1007/s00436-002-0751-z
复制
发表时间：
2003-06-01
影响因子：
2
通讯作者：
Pica-Mattoccia, L
中科院分区：
文献类型：
--
作者：
Cioli, D;Pica-Mattoccia, L
吡喹酮是治疗各种血吸虫病的首选药物。这篇综述总结了药物的主要特点，特别注意那些方面，可能是感兴趣的执业医师。在简要介绍了历史，化学，主要可用的品牌及其成本，剂量和管理时间表进行审查。分析了其药代动力学和药物相互作用，强调其毒性低、副作用轻。吡喹酮的一个主要弱点是其对近期感染相对无效，这一因素偶尔可能导致高流行地区的治愈率较低。最近的研究结果，吡喹酮敏感性下降的嗜酸性粒细胞分离株进行了讨论，在更广泛的背景下，可能出现的耐药性。
Praziquantel is the drug of choice for the treatment of all forms of schistosomiasis. This review summarizes the main features of the drug, with special attention being given to those aspects that may be of interest to the practicing physician. After a brief mention of the history, the chemistry, the major available brands and their costs, doses and administration schedules are reviewed. Pharmacokinetics and drug interactions are analyzed and the low toxicity and mild side effects are stressed. A major weakness of praziquantel is its relative inefficacy against recent infections, a factor that may occasionally result in low cure rates in hyperendemic areas. Recent findings of schistosome isolates with a decreased sensitivity to praziquantel are discussed in the broader context of a possible emergence of drug resistance.