Total Synthesis and Stereochemistry Assignment of Nucleoside Antibiotic A‐94964
Total Synthesis and Stereochemistry Assignment of Nucleoside Antibiotic A‐94964
复制标题
核苷抗生素 A-94964 的全合成和立体化学归属
DOI：
10.1002/anie.202200818
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Yu Biao
中科院分区：
文献类型：
--
作者：
Shao Xiaofei;Zheng Chang;Xu Peng;Shiraishi Taro;Kuzuyama Tomohisa;Molinaro Antonio;Silipo Alba;Yu Biao
八种非对映异构体的集体全合成与NMR分析相关，导致结构独特的核苷抗生素A-94964的完整立体化学归属，其特征在于通过磷酸二酯桥修饰有α-D-吡喃甘露糖残基和α-D-N-酰基葡萄糖胺吡喃糖残基的辛醛酸尿苷核心。
A collective total synthesis of eight diastereoisomers associated with NMR analysis leads to a full stereochemistry assignment of the structurally unique nucleoside antibiotic A‐94964, which features an octuronic acid uridine core decorated with an α‐D‐mannopyranosyl residue and an α‐D‐N‐acylglucosaminopyranosyl residue via a phosphodiester bridge.