Characterisation of a soft elastomer poly(glycerol sebacate) designed to match the mechanical properties of myocardial tissue
Characterisation of a soft elastomer poly(glycerol sebacate) designed to match the mechanical properties of myocardial tissue
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DOI：
10.1016/j.biomaterials.2007.09.010
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发表时间：
2008-01-01
期刊：
影响因子：
14
通讯作者：
Boccaccini, Aldo R.
中科院分区：
文献类型：
--
作者：
Chen, Qi-Zhi;Bismarck, Alexander;Boccaccini, Aldo R.
心肌组织缺乏显著的内在再生能力来替代丢失的细胞。因此，心脏是组织工程领域的主要研究对象，其目的是替代梗死心肌并增强心脏功能。本工作的主要目的是开发一种生物相容性，可降解和超弹性的聚（甘油癸二酸酯）（PGS）心脏补片。在110、120和130 ℃下通过甘油和癸二酸以1：1的摩尔比缩聚来合成PGS。调查的重点是开发的PGS的机械和生物降解行为。在110、120和130 ℃下合成的PGS材料的杨氏模量分别为0.056、0.22和1.2MPa，满足心脏补片和三维心肌组织工程构建材料的力学要求。在磷酸盐缓冲盐水和Knockout（TM）DMEM培养基中的降解评估已经证明PGS具有宽范围的降解性，从在几周内可降解到几乎惰性。物理特性与心脏的匹配、在生物相关介质中微调降解速率的能力以及显示生物相容性的初始数据表明，该材料有望用于心脏组织工程应用。(c)2007爱思唯尔有限公司保留所有权利。
The myocardial tissue lacks significant intrinsic regenerative capability to replace the lost cells. Therefore, the heart is a major target of research within the field of tissue engineering, which aims to replace infarcted myocardium and enhance cardiac function. The primary objective of this work was to develop a biocompatible, degradable and superelastic heart patch from poly(glycerol sebacate) (PGS). PGS was synthesised at 110, 120 and 130 degrees C by polycondensation of glycerol and sebacic acid with a mole ratio of 1:1. The investigation was focused on the mechanical and biodegrading behaviours of the developed PGS. PGS materials synthesised at 110, 120 and 130 degrees C have Young's moduli of 0.056, 0.22 and 1.2MPa, respectively, which satisfy the mechanical requirements on the materials applied for the heart patch and 3D myocardial tissue engineering construction. Degradation assessment in phosphate buffered saline and Knockout (TM) DMEM culture medium has demonstrated that the PGS has a wide range of degradability, from being degradable in a couple of weeks to being nearly inert. The matching of physical characteristics to those of the heart, the ability to fine tune degradation rates in biologically relevant media and initial data showing biocompatibility indicate that this material has promise for cardiac tissue engineering applications. (c) 2007 Elsevier Ltd. All rights reserved.