Competition between cell types under cell cycle regulation with apoptosis
Competition between cell types under cell cycle regulation with apoptosis
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DOI：
10.1103/physrevresearch.4.033156
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发表时间：
2022-08
影响因子：
4.2
通讯作者：
Jintao Li;S. Schnyder;M. S. Turner;R. Yamamoto
中科院分区：
文献类型：
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作者：
Jintao Li;S. Schnyder;M. S. Turner;R. Yamamoto
不同细胞类型之间的竞争在细菌生态学、发育生物学和肿瘤生长中起着至关重要的作用。我们研究细胞如何通过使用平均场理论和基于粒子的模拟在2D中竞争。我们采用了一个机械模型，结合了程式化的形式的细胞周期调控，以控制细胞分裂事件。这被扩展到治疗具有不同的程序性细胞死亡（凋亡）速率和特征性细胞周期控制压力的多种细胞类型。入侵速度和共存线的分析预测与模拟一致。细胞分裂/凋亡事件中的同步可以出现，导致压力和细胞周期活性的振荡。我们还研究了小（前）癌集落的侵袭或消除。我们展示了如何在殖民地界面的拉普拉斯压力，在这里由差分细胞粘附控制，改变共存线;有细胞类型，可以入侵时，从一个大的集落开始，但将被淘汰，如果殖民地是小的。
Competition between different cell types plays a crucial role in bacterial ecology, developmental biology, and tumor growth. We study how cells compete in 2D by using both a mean field theory and particle-based simulations. We employ a mechanical model that incorporates a stylized form of cell cycle regulation to control cell division events. This is extended to treat multiple cell types with different rates of programed cell death (apoptosis) and characteristic cell-cycle control pressures. Analytic predictions for the invasion speed and the coexistence line are in agreement with simulations. Synchronization in the cell division/apoptosis events can emerge, leading to oscillations in pressure and cell-cycle activity. We also study the invasion or elimination of small (pre)cancerous colonies. We show how a Laplace pressure at the colony interface, here controlled by differential cell adhesion, shifts the coexistence line; there are cell types that can invade when starting from a large colony but will be eliminated if the colony is small.