Distribution of Hepatitis B Virus Genotypes in Two Different Pediatric Populations from Argentina
Distribution of Hepatitis B Virus Genotypes in Two Different Pediatric Populations from Argentina
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阿根廷两个不同儿童群体中乙型肝炎病毒基因型的分布
DOI：
10.1128/jcm.36.11.3362-3365.1998
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发表时间：
1998
影响因子：
9.4
通讯作者：
R. H. Campos
中科院分区：
文献类型：
--
作者：
V. Mbayed;J. López;P. F. Telenta;Gustavo Palacios;I. Badia;A. Ferro;C. Galoppo;R. H. Campos
发病机制的差异和成为慢性乙肝病毒携带者的可能性取决于获得乙肝病毒（HBV）感染的年龄，从6个月以下婴儿的82%到年龄较大儿童的15 - 30%不等。已经确定了来自两个不同流行地区的22名儿科患者的HBV基因型。系统发育分析显示，低流行地区布宜诺斯艾利斯的基因型分布与高流行地区巴西中部瓜列圭的基因型分布存在明显差异。虽然分析将布宜诺斯艾利斯组的序列划分为基因型A（36%）、D（9%）和F(55%)，但瓜列圭组只发现基因型A分离株，核苷酸差异非常低，这表明存在强大的创始人病毒群体。基因型F在布宜诺斯艾利斯组的高流行率及其高组内异质性与该基因型的美洲起源一致。
ABSTRACT Differences in pathogenesis and the probability of becoming a chronic carrier depend on the age at which hepatitis B virus (HBV) infection is acquired, ranging from 82% in infants less than 6 months of age to 15 to 30% in older children. HBV genotypes from 22 pediatric patients from two areas that differ in prevalence have been determined. Phylogenetic analysis shows a clear difference between the genotype distribution in Buenos Aires, a low-prevalence area, and that found in Gualeguay, Entre Rı́os, a high-prevalence area. While the analysis allocated the sequences in the Buenos Aires group to genotypes A (36%), D (9%), and F (55%), the Gualeguay group presented exclusively genotype A isolates with very low nucleotide divergence, which suggests a strong founder viral population. The high prevalence of genotype F in the Buenos Aires group and its high intragroup heterogeneity agree with the American origin of this genotype.