Urinary and sexual function after radical prostatectomy for clinically localized prostate cancer - The prostate cancer outcomes study
Urinary and sexual function after radical prostatectomy for clinically localized prostate cancer - The prostate cancer outcomes study
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DOI：
10.1001/jama.283.3.354
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发表时间：
2000-01-19
影响因子：
120.7
通讯作者：
Potosky, AL
中科院分区：
文献类型：
--
作者：
Stanford, JL;Feng, ZD;Potosky, AL
背景前列腺癌患者和他们的医生需要了解治疗方案和潜在的并发症，但有限的数据并发症可在前列腺癌人群为基础的cohort of patients.Objective测量泌尿和性功能的变化在男性谁经历了根治性切除术临床局限性前列腺癌设计前列腺癌预后研究，一项基于人群的纵向队列研究，随访长达24个月。在美国6个地理区域建立基于人群的癌症登记处。参与者共有1291名黑人、白色、以及在1994年10月1日至1995年10月31日期间被诊断为患有原发性前列腺癌的39至79岁的西班牙裔男性，和在诊断为临床局限性疾病的6个月内接受根治性尿道切除术的患者。主要结果测量患者在基线和6，12，结果根治性尿道切除术后18个月及以上，8.4%的患者出现尿失禁，59.9%的患者出现阳萎。在手术前有效的男性中，手术后18个月或更长时间报告阳痿的男性比例因手术是否保留神经而异（65.6%的非神经保留，58.6%的单侧和56.0%的双侧神经保留）。在术后18个月或更长时间，41.9%的人报告说他们的性行为是一个中度到严重的问题。性功能和排尿功能均随年龄而变化（39.0%的男性年龄
Context Patients with prostate cancer and their physicians need knowledge of treatment options and their potential complications, but limited data on complications are available in unselected population-based cohorts of patients.Objective To measure changes in urinary and sexual function in men who have undergone radical prostatectomy for clinically localized prostate cancer.Design The Prostate Cancer Outcomes Study, a population-based longitudinal cohort study with up to 24 months of follow-up.Setting Population-based cancer registries in 6 geographic regions of the United States.Participants A total of 1291 black, white, and Hispanic men aged 39 to 79 years who were diagnosed as having primary prostate cancer between October 1, 1994, and October 31, 1995, and who underwent radical prostatectomy within 6 months of diagnosis for clinically localized disease.Main Outcome Measures Distribution of and change in urinary and sexual function measures reported by patients at baseline and 6, 12, and 24 months after diagnosis.Results At 18 or more months following radical prostatectomy, 8.4% of men were incontinent and 59.9% were impotent. Among men who were potent before surgery, the proportion of men reporting impotence at 18 or more months after surgery varied according to whether the procedure was nerve sparing (65.6% of non-nerve-sparing, 58.6% of unilateral, and 56.0% of bilateral nerve-sparing). At 18 or more months after surgery, 41.9% reported that their sexual performance was a moderate-to-large problem. Both sexual and urinary function varied by age (39.0% of men aged