[14C]urea breath test for diagnosis of Helicobacter pylori.
[14C]urea breath test for diagnosis of Helicobacter pylori.
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[14C]尿素呼气试验诊断幽门螺杆菌。
DOI：
10.1007/bf01536802
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发表时间：
1990
影响因子：
3.1
通讯作者：
Phillips,SF
中科院分区：
文献类型：
--
作者：
Ormand,JE;Talley,NJ;Carpenter,HA;Shorter,RG;Conley,CR;Wilson,WR;DiMagno,EP;Zinsmeister,AR;Phillips,SF
H.幽门螺杆菌是一种有效的尿素酶产生者，这一特征已在[14 C]和[13 C]尿素呼气试验的开发中得到利用。H.幽门螺杆菌感染也被认为是随着年龄的增长而增加，然而，在解释尿素呼气试验结果时，个体患者的年龄并没有被常规地考虑。本研究的目的是验证一个简短的，年龄调整的[14 C]尿素呼气试验用于诊断H。幽门感染。41名受试者（28名志愿者，13名患者）接受了食管胃内窥镜检查和活检。受试者定义为H。pylori阳性，如果组织学或培养阳性。此外，所有受试者均完成了120分钟[14 C]尿素呼气试验。采用logistic回归分析调整年龄，以估计H。pylori阳性作为14 C值的函数生成。16例为H. pylori阳性25例，H.幽门阴性。15 ~ 80分钟之间产生的14 C值在鉴定H.幽门阳性的受试者。年龄越大，H的概率越高。幽门螺杆菌阳性。利用统计概率，老年患者可以准确诊断为H。pylori的14 C值较低。我们发现，[14 C]尿素呼气试验是一种敏感性和特异性试验，可缩短为30分钟检查（总试验时间）。此外，我们的数学模型表明，应考虑患者的年龄，以优化[14 C]尿素呼气试验的解释，尽管需要进一步的观察来确认该模型。
H. pylori is a potent urease producer, a characteristic that has been exploited in the development of the[14C]- and [13C]urea breath tests. The prevalence of H. pylori infection also is known to increase with advancing age; however, the individual patient's age has not routinely been considered when interpreting urea breath test results. The aim of this study was to validate a short, age-adjusted [14C] urea breath test for use in diagnosing H. pylori infections. Forty-one subjects (28 volunteers, 13 patients) underwent esophagogastroduodenoscopy with biopsies. Subjects were defined as being H. pylori positive if histology or culture was positive. In addition, all subjects completed a 120-min [14C]urea breath test. A logistic regression analysis adjusting for age was used to estimate the probability of H. pylori positivity as a function of the14C values generated. Sixteen subjects were H. pylori-positive, and 25 were H. pylori negative. The14C values generated between 15 and 80 min were found to be equally predictive in identifying H. pylori-positive subjects. Advancing age was associated with a higher probability of H. pylori positivity. By taking advantage of the statistical probabilities, older patients could be accurately diagnosed with H. pylori at lower14C values. We found that [14C]urea breath test to be both a sensitive and specific test that can be abbreviated to a 30-min examination (total test time). Moreover, our mathematical model indicates that a patient's age should be considered in order to optimize interpretation of the [14C]urea breath test, although further observations are needed to confirm this model.