Effects of Inhalation of Geranium Essential Oil on Blood Pressure and Heart Rate in Mice
Effects of Inhalation of Geranium Essential Oil on Blood Pressure and Heart Rate in Mice
复制标题
吸入天竺葵精油对小鼠血压和心率的影响
DOI：
10.1177/1934578x19881534
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发表时间：
2019
影响因子：
1.8
通讯作者：
T. Satou
中科院分区：
文献类型：
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作者：
Rhuichiro Masubuchi;Saori Watanabe;T. Satou
为了更好地科学理解芳香疗法的基础知识，我们的研究小组试图阐明天竺葵精油（EOPG，天竺葵精油）的功效，该精油用于尝试和平衡身心联系。为了消除任何可能的安慰剂效应，我们使用了被认为对安慰剂效应不敏感的动物实验。小鼠尾动脉的血压和心率测量被用来反映身心平衡。吸入EOPG（5μL/L空气）90分钟后30分钟，测量小鼠的血压和心率。 EOPG 显着降低血压和心率。为了进一步阐明造成这些影响的因素，进行了气相色谱分析，以确定吸入 EOPG 后转移到大脑中的成分。吸入 10 µL/L EOPG 后，在大脑组织中检测到芳樟醇、香茅醇和香叶醇的浓度约为 0.1 nL/L。然而，吸入 5 µL/L EOPG 后并未检测到这些物质，因为其水平低于检测限。这些结果表明，吸入 EOPG 可能会降低血压和心率，其所表达的效果与芳樟醇等成分转移到大脑有关。
For a better scientific understanding of the basics of aromatherapy, our research group attempted to clarify the effectiveness of the essential oil from Pelargonium graveolens (EOPG, geranium essential oil), which is used to try and balance the mind-body connection. In order to eliminate any possible placebo effect, we used animal experiments that are considered to be insensitive to the placebo effect. Measurements of blood pressure and heart rate in the mouse tail artery were used as a reflection of the mind-body balance. Thirty minutes after inhalation of EOPG (5 µL/L air) for 90 minutes, blood pressure and heart rate of the mice were measured. EOPG significantly reduced blood pressure and heart rate. To further clarify the factors responsible for these effects, gas chromatography analysis was performed in order to determine the components transferred into the brain after the EOPG inhalation. Linalool, citronellol, and geraniol were detected at concentrations around 0.1 nL/L tissue from the brain after 10 µL/L air inhalation of EOPG. However, these were not detected after a 5 µL/L air inhalation of EOPG, as the levels were below the detection limit. These results suggest EOPG inhalation might lower blood pressure and heart rate, with the expressed effects associated with the transfer of components such as linalool into the brain.