Effects of aging on basement membrane-related gene expression of the skeletal muscle in rats
Effects of aging on basement membrane-related gene expression of the skeletal muscle in rats
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DOI：
10.2220/biomedres.42.115
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发表时间：
2021-01-01
影响因子：
1.2
通讯作者：
Shigeyoshi, Yasufumi
中科院分区：
文献类型：
--
作者：
Kanazawa, Yuji;Nagano, Mamoru;Shigeyoshi, Yasufumi
基底膜（BM）以IV型胶原为主要成分，在维持肌肉结构及其坚固性方面起着重要作用。为了研究衰老对脑基构建相关因子的影响，我们比较了这些因子在3月龄和20月龄雄性Wistar大鼠中的表达情况。Col4a1和Col4a2（编码胶原IV）、Sparc（参与胶原IV功能化）和Mmp14（胶原IV降解因子）的表达水平降低。这些结果表明，衰老抑制了IV型胶原合成和降解因子，并在稳态下影响了bm相关因子。
The basement membrane (BM), with collagen IV as a major component, plays an important role in the maintenance of muscle structure and its robustness. To investigate the effects of aging on factors related to BM construction, we compared the expression status of these factors in 3- and 20-month-old male Wistar rats. The expression levels of Col4a1 and Col4a2 (encoding collagen IV), Sparc (involved in collagen IV functionalization), and Mmp14 (a collagen IV degradation factor) were decreased. These results suggest that aging suppresses collagen IV synthetic and degradative factors and affects BM-related factors in the steady state.