Electrophysiological models for the heterogeneous canine atria: computational platform for studying rapid atrial arrhythmias.
Electrophysiological models for the heterogeneous canine atria: computational platform for studying rapid atrial arrhythmias.
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DOI：
10.1109/iembs.2011.6090486
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Zhang H
中科院分区：
文献类型：
--
作者：
Aslanidi OV;Butters TD;Ren CX;Ryecroft G;Zhang H
电动作电位（AP）特性的异质性可以为房性心律失常提供基础，特别是在快速起搏速率下。为了量化这些基板，我们开发了一个家庭的详细的AP模型犬心房细胞。基于犬的电生理数据，对犬右心房（RA）肌细胞的现有模型进行了修改，以创建犬左心房（LA）、心房间Bachmann束（BB）和肺静脉（PV）的新模型。将异质AP模型并入组织链模型中以模拟AP传播，并用于量化犬心房中传导异常的条件（主要是快速起搏时的传导阻滞）。
Heterogeneity in the electrical action potential (AP) properties can provide a substrate for atrial arrhythmias, especially at rapid pacing rates. In order to quantify such substrates, we develop a family of detailed AP models for canine atrial cells. An existing model for the canine right atrial (RA) myocyte was modified based on electrophysiological data from dog to create new models for the canine left atrium (LA), the interatrial Bachmann’s bundle (BB), and the pulmonary vein (PV). The heterogeneous AP models were incorporated into a tissue strand model to simulate the AP propagation, and used to quantify conditions for conduction abnormalities (primarily, conduction block at rapid pacing rated) in the canine atria.