Zinc and the immune system
Zinc and the immune system
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DOI：
10.1017/s0029665100000781
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发表时间：
2000-11-01
影响因子：
7
通讯作者：
Gabriel, P
中科院分区：
文献类型：
--
作者：
Rink, L;Gabriel, P
锌是所有生物体必需的微量元素。在人类受试者中，身体生长和发育严格依赖于Zn。神经，生殖和免疫系统特别受到锌缺乏的影响，以及锌水平的增加。锌和免疫系统之间的关系是复杂的，因为有四种不同类型的影响与锌有关。(1)锌的饮食摄入量和再吸收取决于饮食的组成以及年龄和疾病状态。(2)锌是影响各种器官功能的300多种酶的辅因子，对免疫系统具有次要作用。(3)锌对白细胞生成、成熟和功能的直接影响。(4)锌影响实验系统中使用的免疫刺激剂的功能。在这里，我们总结了所有四种类型的影响免疫功能。锌的营养方面，锌的生理，锌对酶和细胞功能的影响，锌对白细胞在细胞和分子水平的直接影响，锌改变免疫刺激剂的功能和锌的治疗用途将详细讨论。
Zn is an essential trace element for all organisms. In human subjects body growth and development is strictly dependent on Zn. The nervous, reproductive and immune systems are particularly influenced by Zn deficiency, as well as by increased levels of Zn. The relationship between Zn and the immune system is complex, since there are four different types of influence associated with Zn. (1) The dietary intake and the resorption of Zn depends on the composition of the diet and also on age and disease status. (2) Zn is a cofactor in more than 300 enzymes influencing various organ functions having a secondary effect on the immune system. (3) Direct effects of Zn on the production, maturation and function of leucocytes. (4) Zn influences the function of immunostimulants used in the experimental systems. Here we summarize all four types of influence on the immune function. Nutritional aspects of Zn, the physiology of Zn, the influence of Zn on enzymes and cellular functions, direct effects of Zn on leucocytes at the cellular and molecular level, Zn-altered function of immunostimulants and the therapeutic use of Zn will be discussed in detail.