Origin and distribution of capsaicin-sensitive substance P-immunoreactive nerves in the nasal mucosa.
Origin and distribution of capsaicin-sensitive substance P-immunoreactive nerves in the nasal mucosa.
复制标题
鼻粘膜中辣椒素敏感物质P-免疫反应神经的起源和分布。
作者：
L. Lundblad;Johan Lundberg;E. Brodin;A. Änggård
在免疫组化研究中，在豚鼠、大鼠和猫三叉神经节细胞中发现p -免疫反应性物质（SP-IR）。SP-IR神经末梢分布于脊髓三叉神经核、蝶腭神经节细胞周围、血管周围以及鼻黏膜上皮下和内。猫的结扎和去神经支配实验表明蝶腭神经节和鼻黏膜的SP-IR神经属于三叉神经起源。辣椒素预处理豚鼠和大鼠导致鼻黏膜和蝶腭神经节SP-IR神经选择性丧失，而副交感神经和交感神经仍然存在。
In immunohistochemical studies, substance P-immunoreactivity (SP-IR) was found in a population of trigeminal ganglion cells in guinea pig, rat and cat. SP-IR nerve endings were found in the spinal trigeminal nucleus, around sphenopalatine ganglion cells, around blood vessels, as well as under and within the epithelium of the nasal mucosa. Ligation and denervation experiments in the cat indicated that the SP-IR nerves in the sphenopalatine ganglion and the nasal mucosa are of trigeminal origin. Capsaicin pretreatment of guinea pigs and rats resulted in a selective loss of the SP-IR nerves in the nasal mucosa and sphenopalatine ganglion, while the parasympathetic and sympathetic nerves were still present.