Obstructive sleep apnea in children and adolescents with and without obesity
Obstructive sleep apnea in children and adolescents with and without obesity
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DOI：
10.1007/s00405-019-05290-2
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发表时间：
2019-03-01
影响因子：
2.6
通讯作者：
Homoe, Preben
中科院分区：
文献类型：
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作者：
Andersen, Ida Gillberg;Holm, Jens-Christian;Homoe, Preben
目的了解接受肥胖治疗的儿童阻塞性睡眠呼吸暂停(OSA)的患病率，并与正常体重组进行比较。此外，我们还检验了体重指数标准差分数(BMI SDS)和呼吸暂停低通气指数(AHI)之间的关系。方法这项横断面研究包括139名7-18岁超重/肥胖儿童(BMI SDS>；1.28)。正常体重组为33名7~18岁儿童，体重指数SDS1.28。使用3型便携式睡眠监测器(NOX T3)进行睡眠检查。OSA定义为AHI2。结果超重/肥胖儿童阻塞性睡眠呼吸暂停的患病率为44.6%，正常体重组为9.1%(P=0.0002)，相对危险度为4.9(95%可信区间为1.6~14.7)。Logistic回归分析显示，体重指数每增加一个单位，患阻塞性睡眠呼吸暂停的几率增加1.92倍，与年龄、性别、扁桃体肥大和哮喘无关(95%可信区间为1.33-2.76，p=0.0005)。调整了相同变量的广义线性回归显示BMI-SDS和AHI之间存在关联(BMI-SD增加一个单位等于AHI平均增加35%(95%可信区间19-53%，p
PurposeTo investigate the prevalence of obstructive sleep apnea (OSA) in children referred for obesity treatment, and to compare the prevalence with that of a normal-weight group. Moreover, we examined the association between Body Mass Index Standard Deviation Score (BMI SDS) and the Apnea-Hypopnea Index (AHI).MethodsThis cross-sectional study included 139 children aged 7-18years with overweight/obesity (BMI SDS>1.28) recruited from an obesity treatment clinic. The normal-weight group consisted of 33 children (BMI SDS1.28) aged 7-18years recruited from schools. Sleep examinations were performed using a type 3 portable sleep monitor (Nox T3). OSA was defined as AHI2. Height and weight were measured and the tonsillar size was clinically estimated using the Brodsky scale.ResultsThe OSA prevalence was 44.6% in children with overweight/obesity compared with 9.1% in the normal-weight group (p=0.0002), and the relative risk of OSA was 4.9 (95% CI 1.6-14.7). In a logistic regression, a one-unit increase in the BMI SDS increased the odds of having OSA by a factor of 1.92 independent of age, sex, tonsillar hypertrophy, and asthma (95% CI 1.33-2.76, p=0.0005). A generalized linear regression adjusted for the same variables revealed an association between BMI SDS and AHI (a one-unit increase in the BMI SDS equaled an average increase in the AHI of 35% (95% CI 19-53%, p