Comparative characterization of the human and mouse third ventricle germinal zones.
Comparative characterization of the human and mouse third ventricle germinal zones.
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DOI：
10.1097/nen.0b013e31822200aa
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发表时间：
2011-07
影响因子：
3.2
通讯作者：
Gutmann DH
中科院分区：
文献类型：
--
作者：
Dahiya S;Lee DY;Gutmann DH
Recent evidence indicates differences in neural stem cell (NSC) biology in different brain regions. For example, we demonstrated that neurofibromatosis-1 (NF1) tumor suppressor gene inactivation leads to increased NSC proliferation and gliogenesis in the optic chiasm and brainstem, but not in the cerebral cortex. The differential effect of Nf1 inactivation in the optic nerve and brainstem (in which gliomas commonly form in children with NF1) vs. the cortex (in which gliomas rarely develop) suggests the existence of distinct ventricular zones for gliomagenesis in children and adults. Here, we characterized the third ventricle subventricular zone (tv-SVZ) in young and adult mice and human brains. In children but not adult humans the tv-SVZ contains nestin-positive, glial fibrillary acidic protein (GFAP)-positive, brain fatty acid binding protein-positive and sox2-positive cells with radial processes and prominent cilia. In contrast, the tv-SVZ in young mice contains sox2-positive progenitor cells and ciliated ependymal lining cells, but lacks GFAP-positive, nestin-positive radial glia. As in the lateral ventricle SVZ (lv-SVZ), proliferation in the human and murine tv-SVZ decreases with age. The tv-SVZ in adult mice lacks the hypocellular subventricular zone observed in adult human specimens. Collectively, these data indicate the existence of a subventricular zone relevant to our understanding of glioma formation in children and will assist interpretation of genetically engineered mouse glioma models.
