The acute phase serum zinc concentration is a reliable biomarker for predicting the functional outcome after spinal cord injury
The acute phase serum zinc concentration is a reliable biomarker for predicting the functional outcome after spinal cord injury
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DOI：
10.1016/j.ebiom.2019.03.003
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发表时间：
2019-03-01
期刊：
影响因子：
11.1
通讯作者：
Okada, Seiji
中科院分区：
文献类型：
--
作者：
Kijima, Ken;Kubota, Kensuke;Okada, Seiji
研究背景：脊髓损伤（Spinal cord injury，SCI）是一种严重的疾病，对其功能预后的准确预测是一个迫切需要解决的问题。由于缺乏可靠的预测方法，SCI严重程度和治疗干预效果的急性评估是非常困难的，这是急性SCI治疗发展的主要障碍。方法：建立不同损伤程度的SCI动物模型，观察急性期血清锌浓度与SCI严重程度、功能预后的关系。我们还研究了我们是否可以预测功能预后评估后72小时内SCIin human prospective study.Findings的血清锌浓度：在amouse模型，急性血清锌浓度下降比例SCI严重程度和SCI后12小时的血清锌浓度准确预测功能预后。我们阐明了这种血清锌比例降低的机制，表明活化的单核细胞从血清中摄取锌，然后以严重程度依赖的方式浸润病变区域。对38例脊髓损伤患者的非线性回归分析表明，急性期血清锌浓度对远期功能预后的预测准确性（R-2=0.84）高于其他急性期生物标志物，说明急性期血清锌浓度可能是预测功能预后的有用生物标志物。这种简单的方法将允许更客观的临床试验和开发针对SCI的患者定制治疗。(c)2019年，任作家。由Elsevier B出版。V.这是CC BY-NC-ND许可证（http：//creativecommons.org/licenses/by-nc-nd/4.0/）下的开放获取文章。
Background: Spinal cord injury (SCI) is a devastating disorder for which the accurate prediction of the functional prognosis is urgently needed. Due to the lack of reliable prediction methods, the acute evaluation of SCI severity and therapeutic intervention efficacy is extremely difficult, presenting major obstacles to the development of acute SCI treatment. We herein report a novel method for accurately predicting the functional prognosis using the acute-phase serum zinc concentration after SCI.Methods: Weproduced experimental animal SCImodelswith different prognoses and examined the relationship among the SCI severity, functional outcome, and acute-phase serum zinc concentration. We also examined whether we could predict the functional prognosis by evaluating the serum zinc concentration within 72 h after SCI in a human prospective study.Findings: In amouse model, the acute serumzinc concentrations decreased in proportion to SCI severity and the serumzinc concentrations at 12 h after SCI accurately predicted the functional prognosis. We clarified themechanism underlying this serum zinc proportional decrease, showing that activated monocytes took up zinc from blood-serum and then infiltrated the lesion area in a severity-dependent manner. A non-linear regression analysis of 38 SCI patients showed that the serum zinc concentrations in the acute-phase accurately predicted the long-termfunctional outcome (R-2=0.84) more accurately than any other previously reported acute-phase biomarkers.Interpretation: The acute-phase serum zinc concentration could be a useful biomarker for predicting the functional prognosis. This simple method will allow for more objective clinical trials and the development of patient-tailored treatment for SCI. (c) 2019 The Authors. Published by Elsevier B. V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).