Frailty, hospitalization, and progression of disability in a cohort of disabled older women
Frailty, hospitalization, and progression of disability in a cohort of disabled older women
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DOI：
10.1016/j.amjmed.2005.01.062
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发表时间：
2005-11-01
影响因子：
5.9
通讯作者：
Fried, LP
中科院分区：
文献类型：
--
作者：
Boyd, CM;Xue, QL;Fried, LP
目的：确定先前验证的虚弱表型与新发日常生活活动依赖之间的关联，独立于住院治疗和其他既定的残疾预测因素。 对象： 749 名参加妇女健康与衰老研究 I 的妇女，她们在参加队列时在所有日常生活活动中都是独立的。 方法： 通过每 6 个月一次的家访进行评估和访谈，持续 3 年。使用经过验证的表型（>=以下 3 种：体重减轻、疲惫、行走缓慢、久坐和握力无力）对虚弱进行分类，并通过自我报告确定住院情况。分组时间比例风险模型评估了虚弱、住院治疗和日常生活活动依赖性发展之间的关联，并调整了其他因素。 结果：25% 的队列 (186/749) 在基线时虚弱； 56% (104/186) 的虚弱女性与 20% (23/117) 的非虚弱女性在日常生活活动中产生依赖性（P
PURPOSE: To determine the association between a previously validated frailty phenotype and the development of new-onset dependence in activities of daily living, independent of hospitalizations and other established predictors of disability.SUBJECTS: Seven hundred and forty-nine women enrolled in the Women's Health and Aging Study-I who were independent in all activities in daily living when enrolled in the cohort.METHODS: Assessments and interviews were conducted through home visits at 6-month intervals for 3 years. Frailty was classified using a validated phenotype (>= 3 of the following: weight loss, exhaustion, slow walking, sedentariness, and weak grip), and hospitalizations were identified by self-report. Grouped-time proportional hazard models assessed associations among frailty, hospitalization, and the development of dependence in activities in daily living, adjusting for other factors.RESULTS: Twenty-five percent of the cohort (186/749) were frail at baseline; 56% (104/186) of frail versus 20% (23/117) of nonfrail women developed dependence in activities in daily living (P