Wnt Signaling in Skin Development, Homeostasis, and Disease
Wnt Signaling in Skin Development, Homeostasis, and Disease
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DOI：
10.1101/cshperspect.a008029
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发表时间：
2013-02-01
影响因子：
7.2
通讯作者：
Nusse, Roel
中科院分区：
文献类型：
--
作者：
Lim, Xinhong;Nusse, Roel
皮肤及其附属器构成了身体最大的器官。它的复层上皮可以保护免受脱水、辐射、机械创伤和病原体感染等环境压力的影响，而它的附属物，如毛发和皮脂腺，有助于调节体温，并通过伪装和性信号影响动物互动和社会行为。为了在动态的外部环境中有效地做出反应并发挥作用，皮肤及其附属器具有以精心控制的方式再生的卓越能力。当这种精细调节的稳态过程被破坏时，可能会导致癌症等皮肤病。目前，协调皮肤细胞增殖、分化和模式形成的分子信号仍不完全清楚。越来越明显的是，许多在发育中发挥关键作用的形态发生途径在调节皮肤生物学方面也很重要。其中，Wnt 信号传导已成为控制皮肤模式并影响胚胎和成体干细胞采用皮肤及其附属物的各种细胞谱系的决策的主要途径，以及随后控制分化皮肤细胞的功能。在这里，我们将回顾已建立的概念，并介绍我们对 Wnt 信号在皮肤发育、体内平衡和疾病中发挥的不同作用的理解的最新进展。
The skin and its appendages constitute the largest organ of the body. Its stratified epithelia offer protection from environmental stresses such as dehydration, irradiation, mechanical trauma, and pathogenic infection, whereas its appendages, like hair and sebaceous glands, help regulate body temperature as well as influence animal interaction and social behavior through camouflage and sexual signaling. To respond to and function effectively in a dynamic external environment, the skin and its appendages possess a remarkable ability to regenerate in a carefully controlled fashion. When this finely tuned homeostatic process is disrupted, skin diseases such as cancers may result. At present, the molecular signals that orchestrate cell proliferation, differentiation, and patterning in the skin remain incompletely understood. It is increasingly apparent that many morphogenetic pathways with key roles in development are also important in regulating skin biology. Of these, Wnt signaling has emerged as the dominant pathway controlling the patterning of skin and influencing the decisions of embryonic and adult stem cells to adopt the various cell lineages of the skin and its appendages, as well as subsequently controlling the function of differentiated skin cells. Here we will review established concepts and present recent advances in our understanding of the diverse roles that Wnt signaling plays in skin development, homeostasis, and disease.