Catalyst-Dependent Divergent Synthesis of Pyrroles from 3-Alkynyl Imine Derivatives: A Noncarbonylative and Carbonylative Approach
Catalyst-Dependent Divergent Synthesis of Pyrroles from 3-Alkynyl Imine Derivatives: A Noncarbonylative and Carbonylative Approach
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3-炔基亚胺衍生物的催化剂依赖性发散合成吡咯：非羰基化和羰基化方法
DOI：
10.1002/anie.201405215
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发表时间：
2014-08-04
影响因子：
16.6
通讯作者：
Shi, Min
中科院分区：
文献类型：
--
作者：
Chen, Gen-Qiang;Zhang, Xiao-Nan;Shi, Min
已经开发了一种新的Ru-0-和Rh-I-催化的容易获得的3-炔基亚胺衍生物的非羰基化和羰基化环异构化，以中等至优异的产率有效地提供3，4-稠合或非稠合吡咯衍生物。关键步骤包括分别形成钌卡宾中间体或罗达霉素中间体。在这些反应中，CO可以作为配体或试剂。
A novel Ru-0- and Rh-I-catalyzed noncarbonylative and carbonylative cycloisomerization of readily available 3-alkynyl imine derivatives has been developed to provide 3,4-fused or nonfused pyrrole derivatives efficiently in moderate to excellent yields. The key steps involve the formation of a ruthenium carbenoid intermediate or a rhodacycle intermediate, respectively. In these reactions, CO can serve as a ligand or a reagent.