THE IMPLICATIONS OF TUMOR HETEROGENEITY FOR STUDIES ON THE BIOLOGY AND THERAPY OF CANCER METASTASIS
THE IMPLICATIONS OF TUMOR HETEROGENEITY FOR STUDIES ON THE BIOLOGY AND THERAPY OF CANCER METASTASIS
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DOI：
10.1016/0304-419x(81)90004-4
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发表时间：
1981-01-01
期刊：
影响因子：
--
通讯作者：
FIDLER, IJ
中科院分区：
文献类型：
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作者：
HART, IR;FIDLER, IJ
大多数癌症的致命性可归因于肿瘤细胞扩散到远离原发肿瘤的器官并在其中增殖的能力。因此，治疗癌症的主要问题不是切除原发肿瘤块，而是消除转移。尽管它的临床重要性，癌症转移领域没有吸引其他研究领域，如化学和病毒致癌或肿瘤免疫学的关注。然而，新开发的研究方法和仪器刺激了新的兴趣，转移的研究。
The lethality of most cancers can be attributed to'the ability of tumor cells to spread to and proliferate in organs distant from the primary neoplasm. Therefore, the main problem in treating cancer is not the excision of the primary tumor mass, but the elimination of metastases. Despite its clinical importance, the field of cancer metastasis has not attracted the attention accorded other research areas, such as chemical and viral carcinogenesis or tumor immunology. However, newly developed research approaches and instrumentation have stimulated new interest in studies of metastasis.