REACTIVATION ENABLES MEMORY UPDATING, PRECISION-KEEPING AND STRENGTHENING: EXPLORING THE POSSIBLE BIOLOGICAL ROLES OF RECONSOLIDATION
REACTIVATION ENABLES MEMORY UPDATING, PRECISION-KEEPING AND STRENGTHENING: EXPLORING THE POSSIBLE BIOLOGICAL ROLES OF RECONSOLIDATION
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DOI：
10.1016/j.neuroscience.2013.04.005
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发表时间：
2013-08-06
期刊：
影响因子：
3.3
通讯作者：
Quillfeldt, J. A.
中科院分区：
文献类型：
--
作者：
De Oliveira Alvares, L.;Crestani, A. P.;Quillfeldt, J. A.
虽然关于记忆再巩固的分子和细胞机制已经了解了很多，但其实际的生物学功能仍然不清楚。在这项工作中，我们调查的可能性，三个不同的记忆过程-更新，精确保持和跟踪加强-介导的再巩固在上下文恐惧条件反射。再固化涉及钙通道的激活，用于在再激活期间的去稳定化。我们的研究结果表明，当记忆在与原始信息不匹配的情况下被重新激活时，内容会被修改，即，“更新”。然而，当语境条件与原始条件相匹配时，记忆的再激活有助于其随时间的推移而加强或维持其精确内容。由于L-型电压门控钙通道拮抗剂尼莫地平阻断了这些作用，我们认为，再巩固是支持这些过程的机制。(c)2013年IBRO。由爱思唯尔有限公司出版。保留所有权利。
Although much has been learned regarding the molecular and cellular mechanisms of memory reconsolidation, its actual biological function remains unclear. In this work we investigate the possibility that three different mnemonic processes - updating, precision-keeping and trace strengthening - are mediated by reconsolidation in contextual fear conditioning. Reconsolidation involves the activation of calcium channels for the destabilization during the reactivation. Our results show that when memory is reactivated in a situation that does not match the original information, content is modified, i.e., "updated". However, when the contextual condition matches the original one, memory reactivation contributes either to its strengthening or to the maintenance of its precision content over time. Since the L-type voltage-gated calcium channel antagonist nimodipine blocked these effects, we suggest that reconsolidation is the mechanism supporting these processes. (c) 2013 IBRO. Published by Elsevier Ltd. All rights reserved.