Developmental origins of non-communicable disease: implications for research and public health.
Developmental origins of non-communicable disease: implications for research and public health.
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DOI：
10.1186/1476-069x-11-42
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发表时间：
2012-06-27
期刊：
影响因子：
--
通讯作者：
Heindel JJ
中科院分区：
文献类型：
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作者：
Barouki R;Gluckman PD;Grandjean P;Hanson M;Heindel JJ
这份白色白皮书强调发育期是一个可塑性阶段，它使生物体能够适应环境的变化，通过持续的健康来维持或改善生殖能力。可塑性在产前和产后早期更为突出，即，在细胞分化和特定组织形成期间。这些发育期对环境因素高度敏感，如营养素、环境化学品、药物、感染和其他压力源。营养作用和毒性作用具有许多相同的特征，反映了同一枚硬币的两面。在这两种情况下，生理功能的改变可能会引起，并可能导致非传染性疾病的发展。过去40年来发病率大幅上升的许多重大疾病和机能障碍似乎部分与营养不平衡或接触环境化学品有关的发育因素有关。健康和疾病的发展起源（DOHaD）概念为研究和疾病预防的新策略提供了重要的见解，并且在包括人类在内的物种中具有足够的鲁棒性和可重复性，需要政策和公共卫生响应。因此，这份白色文件得出结论，由于早期发育（在子宫内和出生后的头几年）对营养因素或环境化学品暴露造成的发育中断特别敏感，对以后的健康有潜在的不利影响，研究和疾病预防战略都应更多地关注这些脆弱的生命阶段。
This White Paper highlights the developmental period as a plastic phase, which allows the organism to adapt to changes in the environment to maintain or improve reproductive capability in part through sustained health. Plasticity is more prominent prenatally and during early postnatal life, i.e., during the time of cell differentiation and specific tissue formation. These developmental periods are highly sensitive to environmental factors, such as nutrients, environmental chemicals, drugs, infections and other stressors. Nutrient and toxicant effects share many of the same characteristics and reflect two sides of the same coin. In both cases, alterations in physiological functions can be induced and may lead to the development of non-communicable conditions. Many of the major diseases – and dysfunctions – that have increased substantially in prevalence over the last 40 years seem to be related in part to developmental factors associated with either nutritional imbalance or exposures to environmental chemicals. The Developmental Origins of Health and Disease (DOHaD) concept provides significant insight into new strategies for research and disease prevention and is sufficiently robust and repeatable across species, including humans, to require a policy and public health response. This White Paper therefore concludes that, as early development (in utero and during the first years of postnatal life) is particularly sensitive to developmental disruption by nutritional factors or environmental chemical exposures, with potentially adverse consequences for health later in life, both research and disease prevention strategies should focus more on these vulnerable life stages.