Cartilage oligomeric matrix protein (COMP) levels in digital sheath synovial fluid and serum with tendon injury.
Cartilage oligomeric matrix protein (COMP) levels in digital sheath synovial fluid and serum with tendon injury.
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DOI：
10.2746/042516400777612053
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发表时间：
2000
影响因子：
2.2
通讯作者：
R. Smith;D. Heinegård
中科院分区：
文献类型：
--
作者：
R. Smith;D. Heinegård
软骨寡聚基质蛋白（COMP）是一种非胶原性细胞外基质蛋白，主要存在于软骨中，但也存在于肌腱、韧带和半月板中。对人类的研究表明，它可用作类风湿性关节炎和骨关节炎的预后标志物。本研究调查了肌腱损伤是否有助于血清和腱鞘滑液中COMP的水平在马。COMP水平，通过竞争性ELISA分析，在指鞘滑液中比在血清中高10倍以上。当腱鞘内存在肌腱损伤或脓毒症时，水平显著升高，但在单独的腱鞘炎病例中仅显示轻微的、统计学上不显著的升高。血清中COMP浓度随年龄而变化。与年龄较大的对照马相比，马驹（年龄<或= 1岁）的水平显著（P<0.001）更高。总COMP浓度在一个年龄匹配的肌腱炎组与对照组没有显着差异。因此，腱鞘滑液中COMP水平的测量可用于描述肌腱组织中的过程，而血清水平升高可能比肌腱炎更能代表关节疾病。
Cartilage oligomeric matrix protein (COMP) is a noncollagenous extracellular matrix protein found predominantly in cartilage, but also in tendon, ligament and meniscus. Studies in man have demonstrated that it may be used as a prognostic marker in rheumatoid arthritis and osteoarthritis. The present study investigated whether tendon injury contributes to serum and tendon sheath synovial fluid levels of COMP in horses. COMP levels, analysed by competitive ELISA, in the digital sheath synovial fluid were more than 10-fold higher than in the serum. Levels were significantly raised when tendon damage or sepsis was present within the tendon sheath but showed only mild, statistically insignificant, elevation in cases of tenosynovitis alone. COMP concentrations in serum were found to vary with age. Foals (age < or = 1 year) had significantly (P<0.001) higher levels in comparison to older control horses. Total COMP concentrations in an age-matched group with tendinitis were not significantly different from the control group. Measurements of COMP levels in tendon sheath synovial fluid are therefore useful in depicting processes in tendon tissue, while elevated serum levels are likely to be more representative of joint disease than tendinitis.