Prevalence of magnetic resonance imaging-defined atrophic and hypertrophic phenotypes of knee osteoarthritis in a population-based cohort.
Prevalence of magnetic resonance imaging-defined atrophic and hypertrophic phenotypes of knee osteoarthritis in a population-based cohort.
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DOI：
10.1002/art.33344
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发表时间：
2012-02
影响因子：
--
通讯作者：
Felson, David T.
中科院分区：
文献类型：
--
作者：
Roemer, Frank W.;Guermazi, Ali;Niu, Jingbo;Zhang, Yuqing;Mohr, Andreas;Felson, David T.
通过半定量的MRI评估，在人群队列中描述骨赘与伴随的软骨损伤的相关性，并描述胫骨-股骨膝骨性关节炎的萎缩型和肥大型的发生率。弗雷明翰膝关节骨性关节炎研究的参与者接受了1.5T磁共振成像系统的检查，检查使用的是三平面中等加权脂肪抑制序列。根据蠕虫评分系统对软骨和骨赘进行评分。描述了膝关节严重软骨损伤和伴随的骨赘状态的总体患病率。根据骨赘大小估计严重软骨损伤的优势比使用Logistic回归模型。另一项分析评估了所有10个胫股亚区中没有或仅有微小骨赘(≤2，0-7分)但有严重软骨损伤(萎缩表型)的膝关节，以及有大骨赘(≥5，0-7分)，但没有实质性软骨损伤(肥大表型)的膝关节的放射学骨关节炎状态。研究对象为1248名受试者1597个膝关节。67个大骨赘中有54个(80.6%)软骨损伤严重。随着骨赘大小的增加，严重软骨损伤的风险显著增加。21膝(1.3%)表现为萎缩型。仅3膝(0.2%)表现为肥大表型。大多数严重的胫股软骨损伤的膝关节显示中等到较大的骨赘。骨赘越大，就越有可能出现严重的软骨损伤。少数膝关节表现出所谓的萎缩性表型，也包括没有放射学骨性关节炎的膝关节。肥大表型极为罕见。
To describe the association of osteophytes with concomitant cartilage damage in a population-based cohort using semiquantitative MRI assessment and to describe the prevalence of atrophic and hypertrophic phenotypes of tibio-femoral knee osteoarthritis. Participants of the Framingham Knee Osteoarthritis Study were examined with a 1.5 T MRI system using triplanar intermediate-weighted fat suppressed sequences. Cartilage and osteophytes were assessed according to the WORMS scoring system. Overall prevalence of knees with severe cartilage damage and concomitant osteophyte status was described. The odds ratios of severe cartilage damage according to osteophyte size were estimated using a logistic regression model. An additional analysis assessed knees with absent or only tiny osteophytes (≤2 on a 0-7 scale) in all 10 tibio-femoral subregions but with severe cartilage damage (atrophic phenotype) and knees with large osteophytes (≥5 on a 0-7 scale) and without substantial cartilage damage (hypertrophic phenotype) in regard to radiographic osteoarthritis status. 1597 knees of 1248 subjects were included. 54 of 67 (80.6%) knees with large osteophytes exhibited severe cartilage damage. The risk of severe cartilage damage increased markedly with increasing osteophyte size. 21 knees (1.3%) showed an atrophic phenotype. Only 3 knees (0.2%) exhibited a hypertrophic phenotype. The majority of knees with severe tibio-femoral cartilage damage exhibit moderate to large osteophytes. The larger the osteophyte, the more likely there was severe cartilage damage. A minority of knees exhibits the so-called atrophic phenotype, which also includes knees without radiographic osteoarthritis. The hypertrophic phenotype is extremely rare
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作者：
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