A SALMONELLA LOCUS THAT CONTROLS RESISTANCE TO MICROBICIDAL PROTEINS FROM PHAGOCYTIC-CELLS
A SALMONELLA LOCUS THAT CONTROLS RESISTANCE TO MICROBICIDAL PROTEINS FROM PHAGOCYTIC-CELLS
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DOI：
10.1126/science.2646710
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发表时间：
1989-02-24
期刊：
影响因子：
56.9
通讯作者：
HEFFRON, F
中科院分区：
文献类型：
--
作者：
FIELDS, PI;GROISMAN, EA;HEFFRON, F
兼性胞内病原体造成了重要的健康问题，因为它们绕过了宿主的主要防御机制：专职吞噬细胞的杀伤和降解。确定了毒力和细胞内存活所需的细胞内病原体鼠伤寒沙门氏菌的基因，并显示其在抵抗防御素和可能的吞噬细胞的其他杀微生物机制中具有作用。该基因可能被证明是毒力功能表达的调控元件。
Facultative intracellular pathogens pose an important health problem because they circumvent a primary defense mechanism of the host: killing and degradation by professional phagocytic cells. A gene of the intracellular pathogen Salmonella typhimurium that is required for virulence and intracellular survival was identified and shown to have a role in resistance to defensins and possibly to other microbicidal mechanisms of the phagocyte. This gene may prove to be a regulatory element in the expression of virulence functions.