Simulation of microelectrode impedance changes due to cell growth
Simulation of microelectrode impedance changes due to cell growth
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DOI：
10.1109/jsen.2004.831302
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发表时间：
2004-10-01
影响因子：
4.3
通讯作者：
Domach, MM
中科院分区：
文献类型：
--
作者：
Huang, XQ;Nguyen, D;Domach, MM
观察微电极上细胞生长引起的阻抗变化可以提供有关细胞覆盖率和其他重要数量的信息，如细胞-电极间隙。在本文中，我们使用有限元模拟来计算在与电池大小相当的电极上由电池生长引起的阻抗变化。描述无电池电极阻抗的参数是通过测量得出的。结果表明，对于部分小区覆盖，阻抗幅值有望增加至少100%。我们还报告了阻抗幅值和相位的频率依赖关系，并将模拟结果与集总单元模型进行了比较。模拟结果对于电池大小的电极阵列的设计和建模以及对实验的解释都是重要的。
Observation of impedance changes caused by cell growth on microelectrodes provides information about cell coverage and other important quantities, such as the cell-electrode gap. In this paper, we use finite-element simulations to calculate the impedance changes caused by cell growth on electrodes comparable in size to the cell. Parameters describing the impedance of the electrode without cells are derived from measurement. The results show that the impedance magnitude is expected to increase by at least 100% for partial cell coverage. We also report the frequency dependence of the magnitude and phase of the impedance and compare the simulation results with a lumped-element model. The simulation results are important for the design and modeling of arrays of cell-sized electrodes and also for the interpretation of experiments.