Requirement for γδ T Cells in Allergic Airway Inflammation
Requirement for γδ T Cells in Allergic Airway Inflammation
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DOI：
10.1126/science.280.5367.1265
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发表时间：
1998-05
期刊：
影响因子：
56.9
通讯作者：
C. Zuany‐Amorim;C. Ruffié;S. Haile;B. Vargaftig;P. Pereira;M. Pretolani
中科院分区：
文献类型：
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作者：
C. Zuany‐Amorim;C. Ruffié;S. Haile;B. Vargaftig;P. Pereira;M. Pretolani
导致过敏性哮喘的因素尚不清楚，但所导致的病情被认为是2型T辅助细胞（TH2）反应的结果。在肺变应性炎症模型中，与野生型小鼠相比，缺乏γ δ T细胞的小鼠特异性免疫球蛋白E （IgE）和IgG1以及肺白细胞介素-5 （IL-5）释放以及嗜酸性粒细胞和T细胞浸润减少。在初次免疫时给γ - T细胞缺陷小鼠注射IL-4可恢复这些应答。因此，γ - T细胞对于诱导il -4依赖性IgE和IgG1反应以及th2介导的气道炎症对肽抗原至关重要。
The factors that contribute to allergic asthma are unclear but the resulting condition is considered a consequence of a type-2 T helper (TH2) cell response. In a model of pulmonary allergic inflammation, mice that lacked gammadelta T cells had decreases in specific immunoglobulin E (IgE) and IgG1 and pulmonary interleukin-5 (IL-5) release as well as in eosinophil and T cell infiltration compared with wild-type mice. These responses were restored by administration of IL-4 to gammadelta T cell-deficient mice during the primary immunization. Thus, gammadelta T cells are essential for inducing IL-4-dependent IgE and IgG1 responses and for TH2-mediated airway inflammation to peptidic antigens.