Active Phase and Amplitude Fluctuations of Flagellar Beating
Active Phase and Amplitude Fluctuations of Flagellar Beating
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DOI：
10.1103/physrevlett.113.048101
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发表时间：
2014-07-21
影响因子：
8.6
通讯作者：
Friedrich, Benjamin M.
中科院分区：
文献类型：
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作者：
Ma, Rui;Klindt, Gary S.;Friedrich, Benjamin M.
真核生物的鞭毛在分子马达的振荡动力学的驱动下周期性地跳动，以推动细胞和泵送液体。单个鞭毛节拍的微小但可察觉的波动对鞭毛集合的同步以及有鞭毛的游泳者之间的水动力相互作用具有生理意义。在这里，我们用形状模式分析和极限环重建来表征鞭毛弯曲波的相位和幅度起伏。我们报告了鞭毛振荡的品质因数Q38.0+/-16.7(平均值+/-S.E.)。我们的分析表明，鞭毛波动主要是由活动引起的。使用一个集体电机振荡的最小模型，我们演示了单个电机的随机动力学如何在电机-细胞骨架系统中引起活跃的小数目波动。
The eukaryotic flagellum beats periodically, driven by the oscillatory dynamics of molecular motors, to propel cells and pump fluids. Small but perceivable fluctuations in the beat of individual flagella have physiological implications for synchronization in collections of flagella as well as for hydrodynamic interactions between flagellated swimmers. Here, we characterize phase and amplitude fluctuations of flagellar bending waves using shape mode analysis and limit-cycle reconstruction. We report a quality factor of flagellar oscillations Q 38.0 +/- 16.7 (mean +/- s.e.). Our analysis shows that flagellar fluctuations are dominantly of active origin. Using a minimal model of collective motor oscillations, we demonstrate how the stochastic dynamics of individual motors can give rise to active small-number fluctuations in motor-cytoskeleton systems.