Ten years of tension: single-molecule DNA mechanics
Ten years of tension: single-molecule DNA mechanics
复制标题
DOI：
10.1038/nature01405
复制
发表时间：
2003-01-23
期刊：
影响因子：
64.8
通讯作者：
Smith, SB
中科院分区：
文献类型：
--
作者：
Bustamante, C;Bryant, Z;Smith, SB
DNA的基本特征在双螺旋发现后的半个世纪里得到了阐明。但直到过去十年，研究人员才能够操纵DNA的单个分子，直接测量其机械性能。这些研究阐明了DNA和蛋白质之间相互作用的性质，细胞机器运行的约束条件以及DNA依赖性马达产生的力。
The basic features of DNA were elucidated during the half-century following the discovery of the double helix. But it is only during the past decade that researchers have been able to manipulate single molecules of DNA to make direct measurements of its mechanical properties. These studies have illuminated the nature of interactions between DNA and proteins, the constraints within which the cellular machinery operates, and the forces created by DNA-dependent motors.