Blood Oxygen Level-Dependent MRI of the Myocardium with Multiecho Gradient-Echo Spin-Echo Imaging.
Blood Oxygen Level-Dependent MRI of the Myocardium with Multiecho Gradient-Echo Spin-Echo Imaging.
复制标题
使用多回波梯度回波自旋回波成像进行血氧水平依赖性心肌 MRI。
DOI：
10.1148/radiol.2020191845
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发表时间：
2020
期刊：
影响因子：
19.7
通讯作者：
Setsompop,Kawin
中科院分区：
文献类型：
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作者：
vandenBoomen,Maaike;Manhard,MaryKate;Snel,GertJanH;Han,SoHyun;Emblem,KyrreE;Slart,RiemerHJA;Sosnovik,DavidE;Catana,Ciprian;Rosen,BruceR;Prakken,NiekHJ;Nguyen,ChristopherT;Borra,RonaldJH;Setsompop,Kawin
背景心肌氧合成像可以帮助确定是否存在与心血管风险增加相关的微血管功能障碍。 然而，用当前的无创心脏 MRI 血氧水平依赖 (BOLD) 技术描绘潜在的小氧合变化具有挑战性。目的展示梯度回波自旋回波 (GESE) 回波平面成像序列在动态和定量心跳到心跳 BOLD MRI 中的心脏应用，并结合屏气诱导的 CO2 干预来评估健康人群和高血压人群的序列。材料和方法执行 GESE 回波平面成像序列在 18 名健康参与者和 8 名前瞻性招募的高血压参与者的 3.0-T MRI 系统中进行了研究。使用四参数拟合技术计算每次心跳的 T2 和 T2* 图。感兴趣的间隔区域用于确定每次心跳的 T2 和 T2* 值，并在屏气过程中进行检查以确定 BOLD 变化。 使用非参数Mann-Whitney检验比较健康参与者和高血压参与者的T2和T2*变化。结果GESE平面回波成像方法为健康参与者和高血压参与者提供了空间稳定的每次心跳T2和T2*图，平均T2值分别为43毫秒±5（标准差）和46毫秒±9，平均T2*值为28毫秒±5和22毫秒±5，分别。健康参与者在屏气过程中表现出不断增加的 T2 和 T2* 值，T2 的平均正斜率为每次心跳 0.2 毫秒 ± 0.1，T2* 的平均正斜率为每次心跳 0.2 毫秒 ± 0.1，而对于患有高血压的参与者，这些动态 T2 和 T2* 值的平均负斜率为 T2 每次心跳 -0.2 毫秒 ± 0.2，T2 的平均负斜率为每次心跳 -0.1 毫秒 ± 0.2。 T2*。健康参与者和高血压参与者之间的这些平均斜率差异在 T2 (P< .001) 和 T2* (P< .001) 方面均显着。 结论 梯度回波自旋回波回波平面成像序列提供每次心跳的定量 T2 和 T2* 图，并通过分析屏气期间 T2 和 T2* 的变化，实现动态心跳到心跳血氧水平依赖性 (BOLD) 响应成像干预。这种方法可以识别健康参与者和高血压参与者之间 BOLD 反应的差异。© RSNA，2020 另请参阅本期 Friedrich 的社论。
BackgroundMyocardial oxygenation imaging could help determine the presence of microvascular dysfunction associated with increased cardiovascular risk. However, it is challenging to depict the potentially small oxygenation alterations with current noninvasive cardiac MRI blood oxygen level–dependent (BOLD) techniques.PurposeTo demonstrate the cardiac application of a gradient-echo spin-echo (GESE) echo-planar imaging sequence for dynamic and quantitative heartbeat-to-heartbeat BOLD MRI and evaluate the sequence in populations both healthy and with hypertension in combination with a breath hold–induced CO2intervention.Materials and MethodsGESE echo-planar imaging sequence was performed in 18 healthy participants and in eight prospectively recruited participants with hypertension on a 3.0-T MRI system. T2 and T2* maps were calculated per heartbeat with a four-parameter fitting technique. Septal regions of interests were used to determine T2 and T2* values per heartbeat and examined over the course of a breath hold to determine BOLD changes. T2 and T2* changes of healthy participants and participants with hypertension were compared by using a nonparametric Mann-Whitney test.ResultsGESE echo-planar imaging approach gave spatially stable T2 and T2* maps per heartbeat for healthy participants and participants with hypertension, with mean T2 values of 43 msec ± 5 (standard deviation) and 46 msec ± 9, respectively, and mean T2* values of 28 msec ± 5 and 22 msec ± 5, respectively. The healthy participants exhibited increasing T2 and T2* values over the course of a breath hold with a mean positive slope of 0.2 msec per heartbeat ± 0.1 for T2 and 0.2 msec per heartbeat ± 0.1 for T2*, whereas for participants with hypertension these dynamic T2 and T2* values had a mean negative slope of −0.2 msec per heartbeat ± 0.2 for T2 and −0.1 msec per heartbeat ± 0.2 for T2*. The difference in these mean slopes between healthy participants and participants with hypertension was significant for both T2 (P< .001) and T2* (P< .001).ConclusionGradient-echo spin-echo echo-planar imaging sequence provided quantitative T2 and T2* maps per heartbeat and enabled dynamic heartbeat-to-heartbeat blood oxygen level–dependent (BOLD)-response imaging by analyzing changes in T2 and T2* over the time of a breath-hold intervention. This approach could identify differences in the BOLD response between healthy participants and participants with hypertension.© RSNA, 2020See also the editorial by Friedrich in this issue.