The macrophage and its related cholesterol efflux as a HDL function index in atherosclerosis.
The macrophage and its related cholesterol efflux as a HDL function index in atherosclerosis.
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巨噬细胞及其相关的胆固醇流出作为动脉粥样硬化中 HDL 功能指标。
DOI：
10.1016/j.cca.2016.04.012
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发表时间：
2016
期刊：
影响因子：
5
通讯作者：
Kotani K.
中科院分区：
文献类型：
--
作者：
Yamamoto S;Narita I;Kotani K.
巨噬细胞及其相关的胆固醇流出被认为是动脉粥样硬化形成中与高密度脂蛋白（HDL）功能相关的关键参与者。HDL功能可以通过来自血浆、载脂蛋白B耗尽的血清和/或全血清/血浆的HDL级分中的载脂巨噬细胞和脂质受体之间的反应来评估。最近的研究报道，在患有心脏代谢疾病的患者中观察到HDL的胆固醇流出受损，所述心脏代谢疾病例如血脂异常、糖尿病和慢性肾病。一项以人群为基础的队列研究报告了HDL的胆固醇流出能力与动脉粥样硬化疾病的发病率之间的负相关性，无论血清HDL胆固醇水平如何。此外，在本文中，当我们总结了几项检查胆固醇外排的他汀类药物治疗的临床干预性研究时，暗示了他汀类药物治疗患者的外排可能增加。然而，由于样本量小，缺乏测量外排的统一方案，以及现有研究中没有心血管结局的短期干预期，因此在目前情况下尚未完全确定该效应。需要进一步研究以确定药物对胆固醇流出的影响。随着进一步的研究，胆固醇流出是一个有前途的实验室指标，以了解HDL的功能。
The macrophage and its related cholesterol efflux are considered to be a key player in atherosclerotic formation in relation to the function of high-density lipoprotein (HDL). The HDL function can be evaluated by the reaction between lipid-loaded macrophages and lipid-acceptors in the HDL fraction from the plasma, apolipoprotein B-depleted serum, and/or whole serum/plasma. Recent studies have reported that an impaired cholesterol efflux of HDL is observed in patients with cardiometabolic diseases, such as dyslipidemia, diabetes mellitus, and chronic kidney disease. A population-based cohort study has reported an inverse association between the cholesterol efflux capacity of HDL and the incidence of atherosclerotic disease, regardless of the serum HDL-cholesterol level. Moreover, in this paper, when we summarized several clinical interventional studies of statin treatment that examined cholesterol efflux, a potential increase in the efflux in patients treated with statins was implied. However, the effect was not fully defined in the current situation because of the small sample sizes, lack of a unified protocol for measuring the efflux, and short-term intervention periods without cardiovascular outcomes in available studies. Further investigation is necessary to determine the effect of drugs on cholesterol efflux. With additional advanced studies, cholesterol efflux is a promising laboratory index to understand the HDL function.