Enhanced shear-induced platelet aggregation in acute myocardial infarction
Enhanced shear-induced platelet aggregation in acute myocardial infarction
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DOI：
10.1161/01.cir.99.5.608
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发表时间：
1999-02-09
期刊：
影响因子：
37.8
通讯作者：
Ruggeri, ZM
中科院分区：
文献类型：
--
作者：
Goto, S;Sakai, H;Ruggeri, ZM
背景-在受控流动条件下的实验表明，血管性血友病因子（VWF）与血小板糖蛋白（GP）Ib α和整合素α（IIb）β（3）（GP IIb/IIIa复合物）的结合对于在高剪切速率下的聚集至关重要。我们已经测试了急性心肌梗塞患者的血浆如何影响这一过程。方法和结果-从18名症状发作6小时内的急性心肌梗塞患者和26名没有缺血证据的胸痛综合征对照受试者中获得柠檬酸盐血浆，在患者存在时，正常血小板在高剪切率下的聚集显著高于对照血浆，并且抗GP Ib α和抗GP Ib α（IIb）β（3）单克隆抗体。在10 800 s（-1）时，观察值（平均值+/-SD）为47.6+/-17.8% vs 30.1+/-9.9%（P
Background-Experiments under controlled flow conditions indicate that the binding of von Willebrand factor (VWF) to platelet glycoprotein (GP) Ib alpha and integrin alpha(IIb)beta(3) (GP IIb/IIIa complex) is crucial for aggregation at elevated shear rates. We have tested how the plasma of patients with acute myocardial infarction affects this process.Methods and Results-Citrated plasma was obtained from 18 patients with acute myocardial infarction within 6 hours from the onset of symptoms and from 26 control subjects with chest pain syndrome without evidence of ischemia, Aggregation of normal platelets at high shear rates was significantly greater in the presence of patient than control plasma and was inhibited by both anti-GP Ib alpha and anti-alpha(IIb)beta(3) monoclonal antibodies. The observed values (mean+/-SD) were 47.6+/-17.8% versus 30.1+/-9.9% at 10 800 s(-1) (P