MicroRNA-124 suppresses oral squamous cell carcinoma motility by targeting ITGB1
MicroRNA-124 suppresses oral squamous cell carcinoma motility by targeting ITGB1
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DOI：
10.1016/j.febslet.2010.11.038
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发表时间：
2011-01-03
期刊：
影响因子：
3.5
通讯作者：
Lambert, Daniel W.
中科院分区：
文献类型：
--
作者：
Hunt, Stuart;Jones, Adam V.;Lambert, Daniel W.
与细胞外基质相互作用的分子水平的改变，如整合素，与口腔鳞状细胞癌（OSCC）的侵袭有关。然而，OSCC中整合素表达失调的分子机制尚不清楚。在这里，我们发现microRNA-124，一个在OSCC中下调的小的非编码RNA，能够通过与其3'非翻译区相互作用下调整合素β -1 （ITGB1）的表达。过表达miR-124会减弱内源性ITGB1的表达，降低OSCC细胞的粘附性和运动能力，提示miR-124介导的ITGB1抑制的破坏可能是OSCC进展的关键因素。(C) 2010年欧洲生化学会联合会。Elsevier b.v.版权所有。
Alterations in the levels of molecules which interact with the extracellular matrix, such as integrins, are associated with invasion of oral squamous cell carcinomas (OSCC). The molecular mechanisms underlying dysregulation of integrin expression in OSCC, however, remain unclear. Here, we show that microRNA-124, a small non-coding RNA down-regulated in OSCC, is able to downregulate expression of integrin beta-1 (ITGB1) by interacting with its 3' untranslated region. Over-expression of miR-124 attenuates endogenous ITGB1 expression and reduces the adherence and motility of OSCC cells, suggesting disruption of miR-124-mediated repression of ITGB1 may be a key factor in OSCC progression. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.