Screening of enzyme inhibitors from traditional Chinese medicine.
Screening of enzyme inhibitors from traditional Chinese medicine.
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DOI：
10.2174/138620710793360239
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发表时间：
2010-11
影响因子：
1.8
通讯作者：
Yao Shen;Yuming Hu;Bo Chen;S. Yao
中科院分区：
文献类型：
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作者：
Yao Shen;Yuming Hu;Bo Chen;S. Yao
中医（TCM）已经使用了4000多年。与大型组合化学文库和西方天然产物进行新药发现的高通量筛选（HTS）相比，中药的优势在于其制剂对某些疾病的治疗具有明确的疗效。虽然有效成分尚不明确，但长期实践已发现中药疗效明确，因此从HTS的角度来看，中药应是有价值的先导化合物文库，具有明确的治疗疗效。然而，目前的高温超导技术不容易用于研究中药材，因为它们是为筛选已知浓度下相对纯净的已知化学物质而设计的。相比之下，中药是未知浓度的未知化合物的混合物，在不同植物的样品之间可能存在显著差异。本文综述了中药酶抑制剂筛选的现状及未来研究进展。
Traditional Chinese medicine (TCM) has been used for more than 4000 years. By comparison with large combinatorial chemistry libraries and natural products of the West for high-throughput screening (HTS) of new drugs discovery, an advantage of TCM is that the preparation has clear efficacies on the therapy of some diseases. Although the effective components are not clear, the clear efficacies of TCM have been identified for long time practice, Therefore, TCMs should be valuable lead compound libraries with a definite therapy efficacy from the viewpoint of HTS. Nevertheless, current HTS technologies are not easily adapted to investigate TCMs because they are designed for screening a relatively pure known chemical at a known concentration. In contrast, TCMs are mixtures of unknown compounds in unknown concentrations that may differ markedly between samples from different plants. This article reviews the current and future researches on the enzyme inhibitors screening from TCM.