Increased levels of surfactant protein A and D in bronchoalveolar lavage fluids in patients with bronchial asthma
Increased levels of surfactant protein A and D in bronchoalveolar lavage fluids in patients with bronchial asthma
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DOI：
10.1183/09031936.00.16583100
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发表时间：
2000-11-01
影响因子：
24.3
通讯作者：
Fukuda, T
中科院分区：
文献类型：
--
作者：
Cheng, G;Ueda, T;Fukuda, T
表面活性蛋白(SP)-A和SP-D是C型凝集素中的胶原样糖蛋白，主要由II型细胞合成。最近的研究报道了哮喘患者呼吸道局部产生SP-A和SP-D的可能性，但对哮喘患者肺表面活性蛋白的含量尚未进行研究。因此，分别分析了轻度、稳定的哮喘患者在第一次灌洗为支气管灌洗液(BL)、第二次和第三次灌洗为肺泡灌洗液(AL)时肺表面活性蛋白的组成。此外，还分析了粘膜下分泌物的标志物之一岩藻糖与肺泡灌洗液中表面活性物质蛋白含量之间的相关性，发现哮喘患者肺泡灌洗液和肺泡灌洗液中SP-A的含量均高于正常对照组。AL哮喘患者血中SP-D浓度也较高。支气管炎患者血清SP-A水平与岩藻糖水平呈正相关(r=0.849，P
Surfactant proteins (SP)-A and SP-D are collagen-like glycoproteins belonging to the "collectin" class of C-type lectins, which are primarily synthesized in type II cells. Recent studies reported the possibility of local production of SP-A and SP-D in the airways, but the amounts of surfactant proteins in patients with bronchial asthma have not been studied.The composition of surfactant proteins in mild, stable asthmatics in the first lavage as branchial lavage (BL) and the second and third lavages consecutively as alveolar lavages (AL) were therefore, analysed separately. The co-relationships in the BL between the amounts of surfactant proteins and those of fucose, which is one of the markers of submucosal secretion were also analysed.Increased amounts of SP-A in BL and AL of in asthmatics were found as compared with those in controls. A high concentration of SP-D in the AL asthma patients was also found. The levels of SP-A correlated with those of fucose in patients with branchial asthma (r=0.849, p