Prenatal development of transient receptor potential vanilloid 1-expressing primary sensory projections to sacral autonomic preganglionic neurons
Prenatal development of transient receptor potential vanilloid 1-expressing primary sensory projections to sacral autonomic preganglionic neurons
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DOI：
10.1016/j.neulet.2006.08.067
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发表时间：
2006-10-30
影响因子：
2.5
通讯作者：
Goris, Richard C.
中科院分区：
文献类型：
--
作者：
Funakoshi, Kengo;Nakano, Masato;Goris, Richard C.
盆腔器官的内脏反射由支配盆腔器官的初级传入神经与骶髓中间外侧柱中的副交感节前神经元之间的联系介导。目前的免疫组化研究显示，许多静脉曲张表达瞬时受体电位香草素1（TRPV1），密切apposed到节前神经元胞体在胚胎第16天的小鼠。许多，但不是全部，在中间外侧柱表达TRPV1的静脉曲张也呈降钙素基因相关肽免疫阳性。与此相反，没有神经纤维表达TRPV1投射到交感神经节前细胞柱在腰椎脊髓在产前阶段。本研究的结果提出的可能性，初级传入传递的信号引起的激活TRPV1受体的骶副交感节前神经元。因此，骨盆脊髓反射的功能回路，如尿流入引起的排尿，可能在小鼠的产前阶段发展。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
The visceral reflexes of the pelvic organs are mediated by connections between primary afferents innervating the pelvic organs and parasympathetic preganglionic neurons in the intermediolateral column of the sacral spinal cord. The present immunohistochemical study revealed many varicosities expressing transient receptor potential vanilloid 1 (TRPV1) that were closely apposed to the preganglionic neuronal perikarya at embryonic day 16 in mice. Many, but not all, varicosities expressing TRPV1 in the intermediolateral column were also immunopositive for calcitonin gene-related peptide. In contrast, no nerve fibers expressing TRPV1 projected to the sympathetic preganglionic cell column in the lumbar spinal cord in prenatal stages. The results of the present study raised the possibility that the primary afferents transmit signals elicited by the activation of TRPV1 receptors to the sacral parasympathetic preganglionic neurons. Thus, the functional circuit for pelvic spinal reflexes, such as micturition induced by urine influx, might develop in the prenatal stages in mice. (c) 2006 Elsevier Ireland Ltd. All rights reserved.