An fMRI study of differential neural response to affective pictures in schizophrenia
An fMRI study of differential neural response to affective pictures in schizophrenia
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DOI：
10.1016/j.neuroimage.2004.03.028
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发表时间：
2004-07
期刊：
影响因子：
5.7
通讯作者：
Hidehiko Takahashi;M. Koeda;K. Oda;T. Matsuda;E. Matsushima;M. Matsuura;K. Asai;Y. Okubo
中科院分区：
文献类型：
--
作者：
Hidehiko Takahashi;M. Koeda;K. Oda;T. Matsuda;E. Matsushima;M. Matsuura;K. Asai;Y. Okubo
虽然情绪功能障碍被认为是精神分裂症的基本症状，但研究精神分裂症情绪功能障碍的神经基础的研究很少。利用功能磁共振成像（fMRI）和任务查看情感图片，我们的目的是检查自动情绪反应，并阐明精神分裂症的情绪加工受损的神经基础。15名健康志愿者和15名精神分裂症患者进行了研究。在扫描过程中，受试者被要求指出每张图片给他们的感觉。通过功能磁共振成像（fMRI）测量整个大脑对情感图片的反应。对照组在观看不愉快的图片时招募了包括杏仁核-海马区、前额叶皮质、丘脑、基底神经节、小脑、中脑和视觉皮质在内的神经回路。尽管与对照组的行为结果相同，但患者在回路的组成部分（右侧杏仁核，双侧海马区，内侧前额叶皮层（MPFC），基底神经节，丘脑，小脑，中脑和视觉皮层）中表现出较少的激活。这项研究表明精神分裂症患者情绪处理的神经回路功能异常。特别是，右侧杏仁核和MPFC的激活减少似乎是与精神分裂症患者功能失调的情绪行为相关的重要发现。
Although emotional dysfunction is considered a fundamental symptom of schizophrenia, studies investigating the neural basis of emotional dysfunction in schizophrenia are few. Using functional magnetic resonance imaging (fMRI) and a task viewing affective pictures, we aimed to examine automatic emotional response and to elucidate the neural basis of impaired emotional processing in schizophrenia. Fifteen healthy volunteers and 15 schizophrenics were studied. During the scans, the subjects were instructed to indicate how each of the presented pictures made them feel. Whole brain activities in response to the affective pictures were measured by fMRI. Controls recruited the neural circuit including amygdaloid–hippocampal region, prefrontal cortex, thalamus, basal ganglia, cerebellum, midbrain, and visual cortex while viewing unpleasant pictures. Despite an equal behavioral result to controls, the patients showed less activation in the components of the circuit (right amygdala, bilateral hippocampal region, medial prefrontal cortex (MPFC), basal ganglia, thalamus, cerebellum, midbrain, and visual cortex). This study demonstrated functional abnormalities in the neural circuit of emotional processing in schizophrenia. In particular, decreased activation in the right amygdala and MPFC appears to be an important finding related to dysfunctional emotional behavior in schizophrenia.