Chronic arsenic exposure and adverse pregnancy outcomes in Bangladesh
Chronic arsenic exposure and adverse pregnancy outcomes in Bangladesh
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DOI：
10.1097/01.ede.0000147105.94041.e6
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发表时间：
2005-01-01
期刊：
影响因子：
5.4
通讯作者：
Ali, A
中科院分区：
文献类型：
--
作者：
Milton, AH;Smith, W;Ali, A
背景资料：通过饮用水长期接触砷有可能导致不良妊娠结局，尽管这种关联尚未得到最终证明。这项横断面研究评估了砷在饮用水和自然流产，死产，新生儿death.Methods之间的关联：在这项横断面研究中，533名妇女进行了采访。社会人口学特征、饮用水使用和不良妊娠结局的信息通过结构化的预先测试的访谈者管理的问卷获得。答复者报告共使用了223口管威尔斯井;其中208口威尔斯井使用紫外/可见分光光度法测量水样，15口井使用流动注射氢化物发生原子吸收光谱法测量水样结果：在长期暴露于高浓度砷的饮用水中的参与者中，观察到自发流产和死胎的过度风险，根据参与者的身高、高血压和糖尿病史以及（仅针对新生儿死亡）首次怀孕时的年龄进行调整。将砷浓度大于50 μ g/L与小于或等于50 μ g/L的暴露进行比较，优势比为2.5（95%置信区间= 1.5-4.3）对于自然流产，2.5（1.3-4.9）死产，1.8结论：慢性砷暴露可增加新生儿死亡的危险性。
Background: Chronic exposure to arsenic through drinking water has the potential to cause adverse pregnancy outcomes, although the association has not been demonstrated conclusively. This cross-sectional study assessed the association between arsenic in drinking water and spontaneous abortion, stillbirth, and neonatal death.Methods: In this cross-sectional study, 533 women were interviewed. Information on sociodemographic characteristics, drinking water use, and adverse pregnancy outcomes was obtained through a structured pretested interviewer-administered questionnaire. The respondents reported use of a total of 223 tube wells; for 208 wells, water samples were measured using an ultraviolet/visible spectrophotometry method, whereas 15 were measured by flow-injection hydride generation atomic absorption spectrometry (FIHG-AAS).Results: Excess risks for spontaneous abortion and stillbirth were observed among the participants chronically exposed to higher concentrations of arsenic in drinking water after adjusting for participant's height, history of hypertension and diabetes, and (for neonatal death only) age at first pregnancy. Comparing exposure to arsenic concentration of greater than 50 mug/L with 50 mug/L or less, the odds ratios were 2.5 (95% confidence interval = 1.5-4.3) for spontaneous abortion, 2.5 (1.3-4.9) for stillbirth, and 1.8 (0.9-3.6) for neonatal death.Conclusions: These study findings suggest that chronic arsenic exposure may increase the risk of fetal and infant death.