Hepatocyte growth factor and transforming growth factor-beta stimulate both cell growth and migration of human gastric adenocarcinoma cells.
Hepatocyte growth factor and transforming growth factor-beta stimulate both cell growth and migration of human gastric adenocarcinoma cells.
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肝细胞生长因子和转化生长因子-β 刺激人胃腺癌细胞的细胞生长和迁移。
DOI：
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发表时间：
1992
影响因子：
1.5
通讯作者：
Fumiaki Ito
中科院分区：
文献类型：
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作者：
S. Shibamoto;Makio Hayakawa;T. Hori;Naoto Oku;Keiji Miyazawa;Naomi Kitamura;Fumiaki Ito
肝细胞生长因子（HGF）诱导人胃腺癌MKN-74的散射和细胞迁移。HGF也以剂量依赖的方式显著促进MKN-74细胞的生长，尽管有报道称HGF对肿瘤细胞系的生长具有抗增殖作用。这表明HGF不仅能刺激正常上皮细胞的增殖，还能刺激某些癌细胞的增殖。此外，转化生长因子- β (tgf - β)可以抑制大多数上皮细胞的生长，它可以增强HGF诱导的细胞增殖和迁移。HGF和tgf - β的这些叠加效应可能是某些类型癌症的肿瘤侵袭性和不受控制的生长的原因。
Hepatocyte growth factor (HGF) induced scattering and cell migration of human gastric adenocarcinoma MKN-74. HGF also significantly promoted the growth of MKN-74 cells in a dose-dependent manner, although HGF is reported to be antiproliferative for the growth of tumor cell lines. This result indicates that HGF stimulates cell proliferation of not only normal epithelial cells but also certain carcinoma cells. Furthermore, transforming growth factor-beta (TGF-beta), which is recognized to inhibit the growth of most epithelial cells, additively enhanced both the cell proliferation and migration induced by HGF. These additive effects of HGF and TGF-beta may be responsible for the tumor invasiveness and uncontrolled growth of certain types of carcinoma.
转化生长因子 β 1 抑制培养的胎鼠肝细胞中表皮生长因子受体的内吞作用和下调。
DOI：
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发表时间：
1991
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Baskin,G;Schenker,S;Frosto,T;Henderson,G
通讯作者：
Henderson,G