Parallel evolution of chimeric fusion genes
Parallel evolution of chimeric fusion genes
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DOI：
10.1073/pnas.0503528102
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发表时间：
2005-08-09
影响因子：
11.1
通讯作者：
Begun, DJ
中科院分区：
文献类型：
--
作者：
Jones, CD;Begun, DJ
为了了解新功能是如何产生的，我们必须确定塑造新基因进化的共同模式和机制。在这里，我们利用来自果蝇的三个基因，经纬，adh-芬尼根和adh-twain的数据，来寻找控制新基因进化的进化模式和机制。所有这三个基因都独立地来源于ADH，这使得我们能够使用大量关于果蝇ADH的文献来指导我们的分析。我们发现发生的氨基酸变化在时间、空间和类型上基本相似。这三个基因在形成后不久都经历了快速的适应性氨基酸进化，随后经历了随后的静止和功能限制。这些基因还显示出惊人的相似之处，其中ADH区域的氨基酸变化。我们发现，这些早期的变化往往发生在氨基酸残基上，这些氨基酸残基在果蝇ADH中很少进化。这些缓慢进化的部位的变化通常与果蝇功能丧失或亚形态突变有关。我们的数据表明，从祖先的功能转移可能是嵌合融合基因进化的早期关键一步。我们认为，我们观察到的模式既是一般性的，也是预测性的。
To understand how novel functions arise, we must identify common patterns and mechanisms shaping the evolution of new genes. Here, we take advantage of data from three Drosophila genes, jingwei, Adh-Finnegan, and Adh-Twain, to find evolutionary patterns and mechanisms governing the evolution of new genes. All three of these genes are independently derived from Adh, which enabled us to use the extensive literature on Adh in Drosophila to guide our analyses. We discovered a fundamental similarity in the temporal, spatial, and types of amino acid changes that occurred. All three genes underwent rapid adaptive amino acid evolution shortly after they were formed, followed by later quiescence and functional constraint. These genes also show striking parallels in which amino acids change in the Adh region. We showed that these early changes tend to occur at amino acid residues that seldom, if ever, evolve in Drosophila Adh. Changes at these slowly evolving sites are usually associated with loss of function or hypomorphic mutations in Drosophila melanogaster. Our data indicate that shifting away from ancestral functions may be a critical step early in the evolution of chimeric fusion genes. We suggest that the patterns we observed are both general and predictive.