Piezo-photocatalytic effect mediating reactive oxygen species burst for cancer catalytic therapy
Piezo-photocatalytic effect mediating reactive oxygen species burst for cancer catalytic therapy
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DOI：
10.1039/d1mh00492a
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发表时间：
2021-06-11
影响因子：
13.3
通讯作者：
Ji, Xiaoyuan
中科院分区：
文献类型：
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作者：
Kang, Yong;Lei, Lei;Ji, Xiaoyuan
基于热处理的天然闪锌矿纳米片（NSH 700 NS）异质结的压电光催化疗法被应用于有效地诱导细胞内ROS爆发和癌细胞凋亡。在超声和激光照射下，NSH 700 NS的极化电场和能带弯曲的形成允许在体和它们的界面中的电荷的定向分离，从而最小化电荷复合的可能性。压电光催化效应导致有效的催化性能，表现出高性能的超氧自由基（O-2（-））和羟基自由基（OH）产生和谷胱甘肽（GSH）耗尽，这导致细胞内ROS爆发触发的癌细胞在体外和体内的凋亡。
A piezo-photocatalytic therapy based on thermally treated natural sphalerite nanosheet (NSH700 NS) heterojunction was applied to efficiently induce intracellular ROS burst and apoptosis of cancer cells. Upon ultrasound and laser irradiation, the formation of a polarized electric field and band bending of NSH700 NSs allow the directional separation of charges both in the bulk and their interface, thereby minimizing the probability of charge recombination. The piezo-photocatalytic effect leads to an efficient catalytic performance, exhibiting high-performance superoxide radical (O-2(-)) and hydroxyl radical (OH) generation and glutathione (GSH) depletion, which results in a intracellular ROS burst-triggered apoptosis of cancer cells both in vitro and in vivo.