Tobacco use increases susceptibility to bacterial infection.
Tobacco use increases susceptibility to bacterial infection.
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DOI：
10.1186/1617-9625-4-12
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发表时间：
2008-12-18
影响因子：
3.7
通讯作者：
Scott DA
中科院分区：
文献类型：
--
作者：
Bagaitkar J;Demuth DR;Scott DA
经常吸烟和暴露在二手烟中的人感染细菌的风险增加。烟草烟雾暴露增加了对呼吸道感染的易感性，包括结核病、肺炎和军团病；细菌性阴道病和性传播疾病，如衣原体和淋病；幽门螺杆菌感染；牙周炎；脑膜炎；中耳炎；以及手术后和医院感染。烟草烟雾损害了包括中性粒细胞、单核细胞、T细胞和B细胞在内的白细胞的抗菌功能，为感染风险的增加提供了一个机制上的解释。有必要对这一重要领域进行进一步的流行病学、临床和机制研究。
Active smokers and those exposed to secondhand smoke are at increased risk of bacterial infection. Tobacco smoke exposure increases susceptibility to respiratory tract infections, including tuberculosis, pneumonia and Legionnaires disease; bacterial vaginosis and sexually transmitted diseases, such as chlamydia and gonorrhoea; Helicobacter pylori infection; periodontitis; meningitis; otitis media; and post-surgical and nosocomial infections. Tobacco smoke compromises the anti-bacterial function of leukocytes, including neutrophils, monocytes, T cells and B cells, providing a mechanistic explanation for increased infection risk. Further epidemiological, clinical and mechanistic research into this important area is warranted.