Zika virus and neurological disease--approaches to the unknown.
Zika virus and neurological disease--approaches to the unknown.
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DOI：
10.1016/s1473-3099(16)00125-0
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发表时间：
2016-04
期刊：
影响因子：
--
通讯作者：
Brown D
中科院分区：
文献类型：
--
作者：
Solomon T;Baylis M;Brown D
克服大规模生产这些疫苗的成本或后勤问题现在是紧迫的。总之，在控制非洲脑膜炎带脑膜炎球菌病暴发方面取得了很大进展。然而，现在很明显，单价缀合物疫苗只是一种治标不治本的解决办法，迫切需要多价、蛋白质缀合物或新型DNA疫苗，其数量至少可以例行提供给该区域最脆弱的人群。令人担忧的是，导致最近爆发C血清群疾病的克隆来自尼日利亚，该国脊髓灰质炎疫苗的可接受性较差，使世界在根除这种感染方面付出了巨大代价。考虑到这里面临风险的人口规模，现在应该谨慎地予以特别关注，因为如果不在这个地方进行适当的控制，我们可能会为该地区未来的暴发提供脑膜炎球菌基因重组的温床。
Overcoming the cost or logistical issues for the mass production of these vaccines is now urgent. In conclusion, much progress has been made in control of meningococcal disease outbreaks in the meningitis belt of Africa. However, it is now evident that a monovalent conjugate vaccine is only a palliative solution and multivalent, protein conjugate or novel DNA vaccines are urgently needed in quantities that can be offered routinely to at least the most vulnerable people in this region. It is concerning that the clone that caused the recent outbreak of serogroup C disease originated from Nigeria, where poor vaccine acceptability for poliomyelitis has cost the world a great toll in eradication of this infection. It is prudent to pay particular attention now, given the size of the population at risk here, because without adequate control at this location we might have a cesspool for meningococcal genetic recombination for future outbreaks within the region.