Boc groups as protectors and directors for Ir-catalyzed C-H borylation of heterocycles.
Boc groups as protectors and directors for Ir-catalyzed C-H borylation of heterocycles.
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DOI：
10.1021/jo901822b
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发表时间：
2009-12-04
期刊：
影响因子：
--
通讯作者：
Smith MR 3rd
中科院分区：
文献类型：
--
作者：
Kallepalli VA;Shi F;Paul S;Onyeozili EN;Maleczka RE Jr;Smith MR 3rd
发现Ir催化的C-H硼基化与Boc保护基相容。因此，吡咯、吲哚和氮杂吲哚可以在C-H位置β至N处选择性地官能化。Boc基团可以在热处理时除去或在随后的转化过程中保持完整。
Ir-catalyzed C–H borylation is found to be compatible with Boc protecting groups. Thus, pyrroles, indoles, and azaindoles can be selectively functionalized at C–H positions β to N. The Boc group can be removed on thermolysis or left intact during subsequent transformations.