Ia antigen expression on human epidermal Langerhans cells
Ia antigen expression on human epidermal Langerhans cells
复制标题
Ia抗原在人表皮朗格汉斯细胞上的表达
作者：
G. Rowden;M. G. Lewis;A. Sullivan
有人提出，哺乳动物表皮朗格汉斯细胞是网状内皮系统细胞的表皮等效物，参与淋巴结和脾脏中过敏原的结合和呈递1,2。这些驻留细胞能够结合各种过敏原并迁移到淋巴管和局部引流节点，这表明它们在初级免疫反应的传入臂中具有主要功能3,4，并提高了对接触性过敏性超敏反应的理解。关于细胞类型的特征、其与各种抗原的反应性以及其与免疫系统其他细胞的关系，仍有许多待发现。我们在此表明，表皮朗格汉斯细胞通过免疫荧光与兔体内产生的抗人 B 淋巴母细胞系膜糖蛋白的抗血清发生阳性反应，这表明这些树突状细胞上存在 Ia 样抗原。
IT has been proposed that the mammalian epidermal Langerhans cell is an epidermal equivalent of the cells of the reticulo-endothelial system, which are involved in binding and presentation of allergens in lymph nodes and the spleen1,2. The demonstration that these resident cells are capable of binding various allergens and migrate to the lymph vessels and local draining nodes, indicates a major function in the afferent arm of the primary immune response3,4 and has improved understanding of contact allergic hypersensitivity reactions. Much still remains to be discovered concerning the characteristics of the cell type, its reactivity with various antigens, and its relationship to other cells of the immune system. We show here that epidermal Langerhans cells react positively by immunofluorescence with antisera raised in rabbits against human B lymphoblastoid cell line membrane glycoproteins, which indicates the presence of Ia-like antigens on these dendritic cells.