Lack of association of Human T-cell Lymphotrophic Virus Type 1(HTLV-1) infection and rheumatoid arthritis in an endemic area
Lack of association of Human T-cell Lymphotrophic Virus Type 1(HTLV-1) infection and rheumatoid arthritis in an endemic area
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DOI：
10.1007/s10067-002-0661-6
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发表时间：
2003-02-01
影响因子：
3.4
通讯作者：
Mody, GM
中科院分区：
文献类型：
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作者：
Sebastian, D;Nayiager, S;Mody, GM
d 在南非，HTLV-1 感染与脊髓病的关联在夸祖鲁纳塔尔省得到了很好的描述，该地区是 HTLV-1 感染的流行地区。日本的 HTLV-1 感染背景患病率也很高，据报道 HTLV-1 感染与类风湿性关节炎存在显着关联。本研究旨在确定南非夸祖鲁纳塔尔省患有类风湿性关节炎 (RA) 的非洲黑人中 HTLV-1 感染是否存在关联。研究人员随机选择了 110 名患有 RA 的黑人。记录年龄、性别和病程，并进行类风湿因子测试。使用酶联免疫吸附测定评估 HTLV-1 抗体的存在。还使用聚合酶链式反应 (PCR) 研究了外周血单核细胞中前病毒 DNA 的整合。对照数据来自之前报道的一项基于社区的研究，该研究对来自同一地理区域的 1018 名受试者进行了研究。通过血清学或 PCR 检测，所研究的 110 名患者均未出现 HTLV-1 感染阳性。尽管据报道 HTLV-1 感染在日本可能是 RA 的触发因素，但我们未能在患有 RA 的非洲黑人中检测到任何过量的 HTLV-1 感染。我们的研究结果与美国和欧洲的观察结果一致。
dIn South Africa the association of HTLV-1 infection with myelopathy is well described in Kwa Zulu Natal, which is an endemic area for HTLV-1 infection. Japan also has a high background prevalence of HTLV-1 infection, and a significant association of HTLV-1 infection with rheumatoid arthritis has been reported. This study was undertaken to determine whether there was an association with HTLV-1 infection among black Africans with rheumatoid arthritis (RA) in Kwa Zulu Natal, South Africa. A randomly selected group of 110 black people with RA were studied. The age, sex and duration of disease were recorded and a rheumatoid factor test was performed. The presence of antibodies to HTLV-1 was assessed using an enzyme-linked immunosorbent assay. The integration of proviral DNA in peripheral blood monocytes was also studied using the polymerase chain reaction (PCR). Control data were available from a previously reported community-based study of 1018 subjects from the same geographical area. None of the 110 patients studied were positive for HTLV-1 infection by serology or by PCR. Although HTLV-1 infection is reported as a possible triggering agent for RA in Japan, we failed to detect any excess of HTLV-1 infection in black Africans with RA. Our findings are in agreement with observations in the USA and Europe.