Does changing paternity contribute to the risk of intrauterine growth retardation?
Does changing paternity contribute to the risk of intrauterine growth retardation?
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DOI：
10.1046/j.1365-3016.11.s1.7.x
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发表时间：
1997-01-01
影响因子：
2.8
通讯作者：
Johnson, YR
中科院分区：
文献类型：
--
作者：
Krulewitch, CJ;Herman, AA;Johnson, YR
由父亲抗原引发的免疫反应可能是健康胎盘发育、妊娠维持和婴儿生长所必需的。免疫反应不足可能导致宫内生长迟缓（IUGR）。我们推测，亲子关系的改变可能会干扰免疫反应，导致胎盘形成不良，从而导致IUGR。在这篇文章中，我们研究了胎儿宫内发育迟缓的风险与亲子关系的变化。我们使用了犹他州连续怀孕数据集，该数据集包含了怀孕期间妇女的信息。我们将分析限制在141817名有两次或三次妊娠的妇女中。在前一次怀孕中没有IUGR婴儿的妇女，如果她们改变了伴侣，患IUGR的风险增加20-30%。以前有IUGR婴儿的妇女在父亲身份改变后患IUGR的风险没有增加。这些结果可能指向一种免疫机制，或者可能是由于IUGR的未测量的危险因素的残留混杂。进一步研究的数据包含更多的社会人口学和生物学危险因素的IUGR是必要的，以排除残余的混杂。
An immune reaction initiated by paternal antigens may be necessary for healthy placental development, pregnancy maintenance and infant growth. An inadequate immune response may result in intrauterine growth retardation (IUGR). We hypothesised that a change in paternity may interfere with the immune response and cause poor placentation with resultant IUGR. Ln this paper we examine the risk of IUGR associated with changes in paternity. We used the Utah Successive Pregnancies Data Set that contains information on women across their pregnancies. We restricted the analysis to 141 817 women with two or three pregnancies. Women who did not have an IUGR infant in the previous pregnancy were at a 20-30% greater risk of developing IUGR if they had changed partners. Women who had a previous IUGR infant were at no increased risk for IUGR after a change in paternity. These results may point to an immune mechanism or may be as a result of residual confounding of unmeasured risk factors for IUGR. Further studies with data that contain more sociodemographic and biological risk factors for IUGR are necessary to exclude residual confounding.