Tobacco Smoking and Lung Cancer: Perception-changing facts.
Tobacco Smoking and Lung Cancer: Perception-changing facts.
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DOI：
10.12816/0003255
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发表时间：
2013-08
影响因子：
--
通讯作者：
Muhammad Furrukh
中科院分区：
文献类型：
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作者：
Muhammad Furrukh
吸烟仍然是肺癌和其他疾病过程的最确定的原因。在过去的50年里，烟草精炼和过滤器的引入带来了组织学的变化，现在腺癌已成为最常见的亚型。在过去的十年中，吸烟也与其他变量一起沿着成为一种强有力的预后和预测患者特征。本文简要回顾了有关烟草的科学事实，以及吸烟者和非吸烟者肺癌发生的过程和分子途径。本文还回顾了有关吸烟对肺癌预后影响的随机试验证据。
Tobacco smoking remains the most established cause of lung carcinogenesis and other disease processes. Over the last 50 years, tobacco refinement and the introduction of filters have brought a change in histology, and now adenocarcinoma has become the most prevalent subtype. Over the last decade, smoking also has emerged as a strong prognostic and predictive patient characteristic along with other variables. This article briefly reviews scientific facts about tobacco, and the process and molecular pathways involved in lung carcinogenesis in smokers and never-smokers. The evidence from randomised trials about tobacco smoking's impact on lung cancer outcomes is also reviewed.